Signaling danger: toll-like receptors and their potential roles in kidney disease.
- H. Anders, B. Banas, D. Schlöndorff
- BiologyJournal of the American Society of Nephrology
- 1 April 2004
The authors provide an overview on the biology of TLR, summarize the present data on their expression in the kidney, and provide an outlook for the potential roles ofTLR in kidney disease.
The mesangial cell revisited: no cell is an island.
- D. Schlöndorff, B. Banas
- BiologyJournal of the American Society of Nephrology
- 1 June 2009
The existence of cytokine cross-talk seems very likely, given the observations that podocyte injury frequently results in mesangial cell proliferation, whereas mesangIAL cell injury leads to foot process fusion and proteinuria.
Novel role of toll-like receptor 3 in hepatitis C-associated glomerulonephritis.
- M. Wörnle, H. Schmid, D. Schlöndorff
- Biology, MedicineAmerican Journal of Pathology
- 1 February 2006
It is hypothesized that immune complexes containing viral RNA activate mesangial TLR3 during HCV infection, thereby contributing to chemokine/cytokine release and effecting proliferation and apoptosis and establishing a link between viral infections and glomerular diseases.
TLR4 links podocytes with the innate immune system to mediate glomerular injury.
TLR4 is constitutively expressed by podocytes and is upregulated in MPGN, where it may mediate glomerular injury by modulating expression of chemokines; therefore, TLR4 may link podocytes with the innate immune system to mediate MPGN triggered by the deposition of immune complexes.
TNF-like weak inducer of apoptosis (TWEAK) induces inflammatory and proliferative effects in human kidney cells.
- Hua-Xin Gao, S. Campbell, C. Putterman
- Biology, MedicineCytokine
- 1 April 2009
Rare and low-frequency coding variants alter human adult height
- E. Marouli, M. Graff, G. Lettre
- BiologyNature
- 8 December 2016
The results demonstrate that sufficiently large sample sizes can uncover rare and low-frequency variants of moderate-to-large effect associated with polygenic human phenotypes, and that these variants implicate relevant genes and pathways.
Regulatory cell therapy in kidney transplantation (The ONE Study): a harmonised design and analysis of seven non-randomised, single-arm, phase 1/2A trials
- B. Sawitzki, P. Harden, E. Geissler
- MedicineThe Lancet
- 23 May 2020
Kidney injury molecule‐1 and N‐acetyl‐ß‐d‐glucosaminidase in chronic heart failure: possible biomarkers of cardiorenal syndrome
- C. Jungbauer, C. Birner, A. Luchner
- Medicine, BiologyEuropean Journal of Heart Failure
- 1 October 2011
The aim of this study was to assess whether novel markers of kidney injury are elevated in chronic heart failure and CRS.
Rabbit-ATG or basiliximab induction for rapid steroid withdrawal after renal transplantation (Harmony): an open-label, multicentre, randomised controlled trial
- O. Thomusch, M. Wiesener, C. Hugo
- Medicine, BiologyThe Lancet
- 17 December 2016
Detection of autosomal dominant polycystic kidney disease by NMR spectroscopic fingerprinting of urine.
- W. Gronwald, M. Klein, P. Oefner
- Medicine, BiologyKidney International
- 1 June 2011
It is found that NMR fingerprinting of urine differentiates ADPKD from several other kidney diseases and individuals with normal kidney function.
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