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mRNA-Seq whole-transcriptome analysis of a single cell
Next-generation sequencing technology is a powerful tool for transcriptome analysis. However, under certain conditions, only a small amount of material is available, which requires more sensitiveExpand
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Global Analysis of Cdk1 Substrate Phosphorylation Sites Provides Insights into Evolution
Cataloging Kinase Targets Protein phosphorylation is a central mechanism in the control of many biological processes (see the Perspective by Collins). It remains a challenge to determine the completeExpand
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The Developmental Transcriptome of Drosophila melanogaster
Drosophila melanogaster is one of the most well studied genetic model organisms, nonetheless its genome still contains unannotated coding and non-coding genes, transcripts, exons, and RNA editingExpand
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A Recently Evolved Transcriptional Network Controls Biofilm Development in Candida albicans
A biofilm is an organized, resilient group of microbes in which individual cells acquire properties, such as drug resistance, that are distinct from those observed in suspension cultures. Here, weExpand
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An iron homeostasis regulatory circuit with reciprocal roles in Candida albicans commensalism and pathogenesis.
The mammalian gastrointestinal tract and bloodstream are highly disparate biological niches that differ in concentrations of nutrients such as iron. However, some commensal-pathogenic microorganisms,Expand
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Interlocking Transcriptional Feedback Loops Control White-Opaque Switching in Candida albicans
The human pathogen Candida albicans can assume either of two distinct cell types, designated “white” and “opaque.” Each cell type is maintained for many generations; switching between them is rareExpand
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Efficacy of Larotrectinib in TRK Fusion–Positive Cancers in Adults and Children
Background Fusions involving one of three tropomyosin receptor kinases (TRK) occur in diverse cancers in children and adults. We evaluated the efficacy and safety of larotrectinib, a highly selectiveExpand
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The Evolution of Combinatorial Gene Regulation in Fungi
It is widely suspected that gene regulatory networks are highly plastic. The rapid turnover of transcription factor binding sites has been predicted on theoretical grounds and has been experimentallyExpand
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Evolution of alternative transcriptional circuits with identical logic
Evolution of gene regulation is an important contributor to the variety of life. Here, we analyse the evolution of a combinatorial transcriptional circuit composed of sequence-specific DNA-bindingExpand
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The Transcriptomes of Two Heritable Cell Types Illuminate the Circuit Governing Their Differentiation
The differentiation of cells into distinct cell types, each of which is heritable for many generations, underlies many biological phenomena. White and opaque cells of the fungal pathogen CandidaExpand
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