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The pivotal role of tumour necrosis factor alpha in the development of inflammatory hyperalgesia.
1. The hyperalgesic activities in rats of interleukin-1 beta (IL-1 beta), IL-6, IL-8, tumour necrosis factor alpha (TNF alpha) and carrageenin were investigated. 2. IL-6 activated the previouslyExpand
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The pivotal role of tumour necrosis factor α in the development of inflammatory hyperalgesia
1 The hyperalgesic activities in rats of interleukin‐1β (IL‐1β), IL‐6, IL‐8, tumour necrosis factor α (TNFα) and carrageenin were investigated. 2 IL‐6 activated the previously delineatedExpand
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Interleukin-1β as a potent hyperalgesic agent antagonized by a tripeptide analogue
Interleukin-1 (IL-1) describes two inflammatory proteins1, IL-1α and IL-1β, produced by activated macrophages and other cell types2 and encoded by two genes. Their amino acid sequences have only 26%Expand
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Central and peripheral antialgesic action of aspirin-like drugs.
The peripheral and central effects of some non-steroid anti-inflammatory drugs, aspirin, indomethacin, paracetamol and phenacetin were studied by comparing their intraplantar andExpand
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Peripheral analgesia and activation of the nitric oxide-cyclic GMP pathway.
We have previously described the analgesic effect of dibutyryl cyclic GMP or acetylcholine (ACh) injected into rat paws. Since ACh induces nitric oxide (NO) release from endothelial cells, weExpand
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Interleukin‐8 as a mediator of sympathetic pain
1 The hyperalgesic effects of interleukin‐8 (IL‐8), interleukin‐1β (IL‐1β) and carrageenin were measured in a rat paw pressure test. 2 IL‐8 evoked a dose‐dependent hyperalgesia which was attenuatedExpand
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The molecular mechanism of action of peripheral morphine analgesia: stimulation of the cGMP system via nitric oxide release.
In addition to the central and spinal sites of action of morphine both our laboratory and others have demonstrated that opiates can also cause analgesia through a peripheral mechanism (Ferreira,Expand
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Bradykinin initiates cytokine‐mediated inflammatory hyperalgesia
1 The hyperalgesic activities in rats of bradykinin, carrageenin and lipopolysaccharide (LPS) were investigated in a model of mechanical hyperalgesia. 2 Bradykinin and carrageenin evokedExpand
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Cytokine‐mediated inflammatory hyperalgesia limited by interleukin‐4
The effect of IL‐4 on responses to intraplantar (i.pl.) carrageenin, bradykinin, TNFα, IL‐1β, IL‐8 and PGE2 was investigated in a model of mechanical hyperalgesia in rats. Also, the cellular sourceExpand
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Involvement of bradykinin, cytokines, sympathetic amines and prostaglandins in formalin‐induced orofacial nociception in rats
This study characterises some of the mechanisms and mediators involved in the orofacial nociception triggered by injection of formalin into the upper lip of the rat, by assessing the influence ofExpand
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