• Publications
  • Influence
Genetic variation in human NPY expression affects stress response and emotion
TLDR
It is shown that haplotype-driven NPY expression predicts brain responses to emotional and stress challenges and also inversely correlates with trait anxiety, consistent with the function of NPY as an anxiolytic peptide and help to explain inter-individual variation in resiliency to stress. Expand
Impaired recognition of fear facial expressions in 5-HTTLPR S-polymorphism carriers following tryptophan depletion
TLDR
The effects of acute tryptophan depletion on the processing of emotional expressions varies as a function of genotype at the 5-HTTLPR, and reinforces the importance of considering genotype when assessing the behavioral effects of pharmacologic modulation. Expand
Blockade of Nociceptin/Orphanin FQ Transmission Attenuates Symptoms and Neurodegeneration Associated with Parkinson's Disease
TLDR
Evidence suggesting that endogenous N/OFQ may contribute to Parkinson's disease is presented and it is proposed that NOP receptor antagonists may represent a novel approach for combined (symptomatic and neuroprotective) therapy of Parkinson’s disease. Expand
Amygdala Function and 5-HTT Gene Variants in Adolescent Anxiety and Major Depressive Disorder
TLDR
S/L(G) alleles in healthy adolescents, as in healthy adults, predict enhanced amygdala activation to fearful faces, and contrary findings of increased activation in patients with L(A)L(A), relative to the S or L(G), require further exploration. Expand
Quantitative analysis of mu and delta opioid receptor gene expression in rat brain and peripheral ganglia using competitive polymerase chain reaction
TLDR
The reverse transcription polymerase chain reaction assay is quantitatively reliable for comparison of messenger RNA levels between different RNA extracts, and sensitive enough to permit the detection and assay of mu and delta opioid receptor gene expression in a single pair of sensory or autonomic ganglia from the rat. Expand
Association of galanin haplotypes with alcoholism and anxiety in two ethnically distinct populations
TLDR
It is suggested that GAL may contribute to vulnerability to alcoholism, perhaps mediated by dimensional anxiety, and seven single-nucleotide polymorphisms spanning GAL were genotyped from five populations. Expand
BDNF gene polymorphism (Val66Met) predicts amygdala and anterior hippocampus responses to emotional faces in anxious and depressed adolescents
TLDR
The contribution of BDNF gene variants to the neural correlates of adolescent anxiety and depression is demonstrated, demonstrating early "gene-brain" linkages may lay the foundation for longer-term patterns of neural dysfunction in affective disorders. Expand
Serotonin polymorphisms and posttraumatic stress disorder in a trauma exposed African American population
TLDR
A relationship between genetic variation in the 5HT2A promoter region and PTSD is suggested, and 5HTTLPR is not found. Expand
Haplotype-based analysis of alpha 2A, 2B, and 2C adrenergic receptor genes captures information on common functional loci at each gene
TLDR
The α2-AR haplotype maps and marker panels are useful tools for genetic linkage studies to detect effects of known and unknownα2- AR functional loci. Expand
Effect of chronic cocaine treatment on mu- and delta-opioid receptor mRNA levels in dopaminergically innervated brain regions.
TLDR
It is suggested that endogenous opioid systems in nucleus accumbens, the brain region specifically associated with the reinforcing properties of addictive drugs, are regulated by dopaminergic mechanisms and influenced by cocaine treatment. Expand
...
1
2
3
4
5
...