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Mild to Moderate Muscular Symptoms with High-Dosage Statin Therapy in Hyperlipidemic Patients —The PRIMO Study
TLDR
It is demonstrated that mild to moderate muscular symptoms with high-dosage statin therapy may be more common and exert a greater impact on everyday lives than previously thought.
Trough imatinib plasma levels are associated with both cytogenetic and molecular responses to standard-dose imatinib in chronic myeloid leukemia.
TLDR
Monitoring of imatinib plasma levels could be very useful for the management of patients with CML or should at least be checked in the case of treatment failure or suboptimal response.
Use of oral corticosteroids in the United Kingdom.
TLDR
Investigation of the usage pattern of oral corticosteroids in a large sample representative of the general population in England and Wales found patients with arthropathies were most likely to use long-term, continuous treatment, and patients with chronic obstructive pulmonary disease least likely.
Improvement in gastrointestinal tolerability of the selective cyclooxygenase (COX)-2 inhibitor, meloxicam, compared with piroxicam: results of the Safety and Efficacy Large-scale Evaluation of
TLDR
The outcome of SELECT is consistent with that of the large-scale clinical trial of similar design and size which compared 7.5 mg meloxicam with 100 mg diclofenac in patients with osteoarthritis, and with a previous global analysis of the safety ofmeloxicam.
Patterns and correlates of benzodiazepine use in the French general population
TLDR
There remains a high proportion of long-term BZD users in the general French population, especially in the elderly, and the findings add the weight of opinion that messages concerning proper use of BZDs certainly need to be clarified and amplified.
Appetite-suppressant drugs and the risk of primary pulmonary hypertension. International Primary Pulmonary Hypertension Study Group.
TLDR
The use of anorexic drugs was associated with the development of primary pulmonary hypertension and active surveillance for this disease should be considered, particularly since their use is expected to increase in the near future.
Antipsychotic prescribing trends: a review of pharmaco‐epidemiological studies
TLDR
Findings from pharmaco‐epidemiological studies exploring antipsychotic drugs prescribing trends are reviewed to review findings from pharmaceuticals prescribing trends.
Benzodiazepine use and risk of Alzheimer’s disease: case-control study
TLDR
The stronger association observed for long term exposures reinforces the suspicion of a possible direct association, even if benzodiazepine use might also be an early marker of a condition associated with an increased risk of dementia.
Admissions to hospital caused by adverse drug reactions: cross sectional incidence study
TLDR
The incidence of admissions caused by adverse drug reactions was calculated by conducting a prospective cross sectional study of a representative nationwide sample of medical wards in public hospitals in French teaching hospitals and general hospitals.
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