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INHIBITION OF DOPAMINE-BETA-HYDROXYLASE BY DISULFIRAM.
INHIBITION OF DOPAMINE-β-HYDROXYLASE BY DISULFIRAM IN VIVO
Disulfiram is a potent inhibitor of dopamine-β-oxidase which lowers norepinephrine content of the tissues. It prevents conversion of dopamine-H3, tyramine-H3 and other phenylethylamines to their… Expand
Inhibition of dopamine- β -hydroxylase by disulfiram
Tremor and Involuntary Movements in Monkeys: Effect of L-Dopa and of a Dopamine Receptor Stimulating Agent
Either L-dopa, in combination with 1-α-methyldopa hydrazine (MK-486), or 1-(2''-pyrimidyl)-4-piperonylpiperazine, an agent that stimulates dopamine receptors, relieves surgically induced tremor in… Expand
Inhibition of dopamine-beta-hydroxylase by disulfiram in vivo.
STUDIES OF AMINES IN THE STRIATUM IN MONKEYS WITH NIGRAL LESIONS
- M. Goldstein, B. Anagnoste, A. Battista, W. Owen, S. Nakatani
- Chemistry, Medicine
- Journal of neurochemistry
- 1 April 1969
The effects of ventromedial tegmental lesions on the biosynthesis and disposition of biogenic amines in the striatum of monkeys were investigated. The concentrations of endogenous dopamine and of the… Expand
Norepinephrine Biosynthesis Inhibition: Effects on Memory in Mice
Diethyldithiocarbamate, a dopamine beta hydroxylase inhibitor, decreases biosynthesis of norepinephrine in the brain. The effects of this inhibitor coincide with alterations in memory as demonstrated… Expand
The effects of ventromedial tegmental lesions on the biosynthesis of catecholamines in the striatum
Abstract Following ventromedial tegmental lesions in the brain stem of monkeys, tyrosine hydroxylase activity is significantly lower on the lesion side of the caudate nucleus and putamen. The in vivo… Expand
The conversion in vivo of D-amphetamine to (+)-p-hydroxynorephedrine.
Drug-induced Relief of the Tremor in Monkeys with Mesencephalic Lesions
MODEL syndromes of extrapyramidal dysfunction have been induced in monkeys by introduction of unilateral lesions into the ventromedial area of the brain stem1. In such cases the destruction of the… Expand