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Either L-dopa, in combination with 1-alpha-methyldopa hydrazine (MK-486), or 1-(2''-pyrimidyl)-4-piperonylpiperazine, an agent that stimulates dopamine receptors, relieves surgically induced tremor… Continue Reading
Disulfiram is a potent inhibitor of dopamine-β-oxidase which lowers norepinephrine content of the tissues. It prevents conversion of dopamine-H3, tyramine-H3 and other phenylethylamines to their… Continue Reading
Diethyldithiocarbamate, a dopamine beta hydroxylase inhibitor, decreases biosynthesis of norepinephrine in the brain. The effects of this inhibitor coincide with alterations in memory as demonstrated… Continue Reading
— The effects of ventromedial tegmental lesions on the biosynthesis and disposition of biogenic amines in the striatum of monkeys were investigated. The concentrations of endogenous dopamine and… Continue Reading
Dibutyryl adenosine 3', 5'-monophosphate (dB-cAMP) stimulates the biosynthesis of 14C-dopamine from 14C-tyrosine in slices obtained from the striatum of rats. The stimulation is due to the cyclic… Continue Reading