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High-throughput chromatin motion tracking in living yeast reveals the flexibility of the fiber throughout the genome.
TLDR
The analysis of the amplitude of fluctuations by the Rouse model shows that yeast chromatin is highly flexible, its persistence length being qualitatively estimated to <30 nm and suggesting that it provides a consistent framework to study chromatin dynamics.
Two RNA Polymerase I Subunits Control the Binding and Release of Rrn3 during Transcription
TLDR
A dual role of the Rpa49-Rpa34 dimer during the recruitment of Rrn3 and its subsequent dissociation from the elongating polymerase is suggested.
RNA polymerase I–specific subunits promote polymerase clustering to enhance the rRNA gene transcription cycle
The Pol I subunits Rpa34 and Rpa49, required for elongation and 35S rRNA production, promote clustering of neighboring Pol I complexes to enhance the rRNA gene transcription cycle.
Structure-function analysis of Hmo1 unveils an ancestral organization of HMG-Box factors involved in ribosomal DNA transcription from yeast to human
TLDR
This study has demonstrated the functional conservation of eukaryotic HMGB proteins involved in ribosome biogenesis and proposed that Hmo1 has acquired species-specific functions and shares with UBF1 and Sp-Hmo1 an ancestral function to stimulate rDNA transcription.
Systematic characterization of the conformation and dynamics of budding yeast chromosome XII
Comprehensive analysis of the intranuclear territories and motion of budding yeast chromosome XII loci suggests that long-range chromosome architecture is mainly determined by the physical principles
A ribosome assembly stress response regulates transcription to maintain proteome homeostasis
TLDR
It is suggested that levels of newly-synthetized RPs, imported into the nucleus but not yet assembled into ribosomes, work to continuously balance Hsf1 and Ifh1 activity, thus guarding against proteotoxic stress during ribosome assembly.
A ribosome assembly stress response regulates transcription to maintain proteome homeostasis
TLDR
It is suggested that levels of newly-synthetized RPs, imported into the nucleus but not yet assembled into ribosomes, work to continuously balance Hsf1 and Ifh1 activity, thus guarding against proteotoxic stress during ribosome assembly.
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