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Oxidative damages are critical in pathogenesis of reflux esophagitis: implication of antioxidants in its treatment.
Gastroprotective Effects of DA-6034, a New Flavonoid Derivative, in Various Gastric Mucosal Damage Models
It is suggested that DA-6034 prevents gastric mucosal injury, and these gastroprotective activities appear to be due to the increase in the gastric defensive systems.
Involvement of oxidative stress in experimentally induced reflux esophagitis and Barrett's esophagus: clue for the chemoprevention of esophageal carcinoma by antioxidants.
Inhibitory effects of DA-9601 on ethanol-induced gastrohemorrhagic lesions and gastric xanthine oxidase activity in rats.
Efficacy of troxerutin on streptozotocin-induced rat model in the early stage of diabetic retinopathy.
- H. K. Chung, S. Choi, B. Ahn, Hyun-Hee Kwak, Jeong Hoon Kim, W. Kim
- Medicine, BiologyArzneimittel-Forschung
- 23 December 2011
It is likely that troxerutin has comparatively effective antioxidant properties and might be a useful treatment for attenuating diabetic retinopathy, and Oxidative stress might be involved in the upregulation of retinal VEGF during early diabetes.
The effect of PDE5 inhibition on the erectile function in streptozotocin-induced diabetic rats
It is suggested that subchronic treatment of DA-8159 can prevent the development of erectile dysfunction (ED), and provides a rationale for the use of DA -8159 as treatment of diabetic ED.
Chronic administration of udenafil, a selective phosphodiesterase type 5 inhibitor, promotes erectile function recovery in an animal model of bilateral cavernous nerve crush injury.
Results from the histological analyses show that udenafil markedly reduces apoptosis induced by CN injury and augments the smooth muscle/collagen ratio, which improves erectile function in a dose- and time-dependent manner.
A rat model for radiation-induced proctitis.
Oxidative stress is more important than acid in the pathogenesis of reflux oesophagitis in rats
Reflux Oesophagitis caused considerable levels of oxidative stress in the oesophageal mucosa and antioxidant treatment should be considered as supplementary therapy in the prevention or treatment of reflux oesphagitis with acid suppression.
Studies on protective effect of DA-9601,Artemisia asiatica extract, on acetaminophen- and CCI4-induced liver damage in rats
- B. Ryu, B. Ahn, T. Oh, S. H. Kim, W. B. Kim, E. B. Lee
- Medicine, BiologyArchives of pharmacal research
- 1 October 1998
It is suggested that pretreatment with DA-9601 may reduce chemically induced liver injury by complex mechanisms which involve prevention of lipid peroxidation and preservation of hepatic GSH.