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Tocilizumab in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial
TLDR
In hospitalised COVID-19 patients with hypoxia and systemic inflammation, tocilizumab improved survival and other clinical outcomes, seen regardless of the amount of respiratory support and were additional to the benefits of systemic corticosteroids. Expand
Azithromycin in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial
TLDR
In patients admitted to hospital with COVID-19, azithromycin did not improve survival or other prespecified clinical outcomes and should be restricted to patients in whom there is a clear antimicrobial indication. Expand
Convalescent plasma in patients admitted to hospital with COVID-19 (RECOVERY): a randomised controlled, open-label, platform trial
TLDR
In patients hospitalised with COVID-19, high-titre convalescent plasma did not improve survival or other prespecified clinical outcomes. Expand
Urinary Excretion and Renal Clearance of Allopurinol in Male Gout Patients
TLDR
Results of this study show that there is slow metabolism of allopurinol inside body due to its extensive bonding with blood proteins. Expand
Production and Characterization of Streptokinase Enzyme by Using Streptococcus mutans Strain in Liquid State Fermentation through Corn Steep Liquor (CSL) Substrate
Background: Enzymes play a very important and central role in the chemical reactions, occurring in biological systems. The study of enzymes has an immense practical importance. They have highExpand
Urinary Excretion and Renal Clearance of Nimesulide in Male Volunteers
TLDR
Urinary excretion and renal clearance of nimesulide after its oral administration correlated with creatinine clearance and statistical analysis was performed in order to determine the significance of the results. Expand
HPLC Analysis and Bio-kinetics Study of Pyrazinamide in Healthy Volunteers After Oral Administration
TLDR
This study was designed to investigate the bio kinetics of Pyrazinamide after oral administration of Py Razinamide (25mg) tablet in 10 healthy volunteers to study the mathematical description of drug changes in the body with time function. Expand
Pharmacokinetics profile of serum and cellular Sofosbuvir along with its concentration effect analysis in HCV patients receiving Sofosbuvir and Ribavirin.
TLDR
The range of therapeutic values was identified for HCV patients receiving sofosbuvir in combination with ribavirin for 24 weeks, suggesting a potential pharmaceutical basis for individualized therapeutic dosing. Expand
Pharmacokinetics profile of serum and cellular Sofosbuvir along with its concentration effect analysis in HCV patients receiving Sofosbuvir and Ribavirin.
Sofosbuvir along with ribavirin is being widely used for treatment of HCV in Pakistan but it may show delayed response and reoccurrence of disease in some cases. The aim of the study was toExpand
Comparative Analysis of Antiglycation Capacity of Aqueous and Methanolic Extracts of Vegetables
Glycation is a reaction between amino group of blood proteins and reducing sugars in vitro conditions which are involved in a number of pathologies and disease states including Alzheimer’s andExpand
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