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Efficacy and Safety of Oral Lacosamide as Adjunctive Therapy in Adults with Partial‐Onset Seizures
Summary:  Purpose: To evaluate the efficacy and safety of lacosamide when added to 1 or 2 antiepileptic drugs (AEDs) in adults with uncontrolled partial‐onset seizures, and assess plasma
Brivaracetam as adjunctive treatment for uncontrolled partial epilepsy in adults: A phase III randomized, double‐blind, placebo‐controlled trial
TLDR
This phase III study was to evaluate the efficacy and safety/tolerability of adjunctive BRV in adults with uncontrolled partial‐onset (focal) seizures.
Partial and generalized epilepsy with febrile seizures plus and a novel SCN1A mutation
TLDR
The findings indicate that partial epilepsy preceded by FS can be associated with sodium channel mutations and may represent a variant of GEFS+.
EEG and ECG in Sudden Unexplained Death in Epilepsy
TLDR
Sudden unexpected death in epilepsy (SUDEP) is a major cause of mortality for patients with epilepsy and cardiac factors may be involved.
Levetiracetam for partial seizures
TLDR
Adjunctive therapy with levetiracetam was effective and well tolerated in controlling partial seizures and was higher than placebo during the entire evaluation period.
Randomized, double-blind, placebo-controlled trial of ezogabine (retigabine) in partial epilepsy
TLDR
This study demonstrates that EZG(RTG) 1,200 mg/day is effective as add-on therapy for reducing seizure frequency in patients with drug-resistant partial-onset seizures.
The course of seizure disorders in patients with malignant gliomas.
TLDR
The occurrence of seizures at diagnosis was a strong predictor of subsequent seizures, and in many patients, seizures proved to be refractory to standard anticonvulsant therapy.
Efficacy and tolerability of the new antiepileptic drugs I: Treatment of new onset epilepsy: Report of the Therapeutics and Technology Assessment Subcommittee and Quality Standards Subcommittee of
TLDR
The results of this evidence-based assessment provide guidelines for the prescription of AEDs for patients with newly diagnosed epilepsy and identify those seizure types and syndromes where more evidence is necessary.
Efficacy and tolerability of the new antiepileptic drugs II: Treatment of refractory epilepsy: Report of the Therapeutics and Technology Assessment Subcommittee and Quality Standards Subcommittee of
TLDR
The results of this evidence-based assessment provide guidelines for the prescription of AEDs for patients with refractory epilepsy and identify those seizure types and syndromes where more evidence is necessary.
De novo mutations in the classic epileptic encephalopathies
TLDR
It is shown that the de novo mutations observed are enriched in specific gene sets including genes regulated by the fragile X protein (P < 10−8), as has been reported previously for autism spectrum disorders.
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