The plasticizer diethylhexyl phthalate induces malformations by decreasing fetal testosterone synthesis during sexual differentiation in the male rat.
Data indicate that DEHP disrupts male rat sexual differentiation by reducing T to female levels in the fetal male rat during a critical stage of reproductive tract differentiation.
Perfluorooctanoic acid induced developmental toxicity in the mouse is dependent on expression of peroxisome proliferator activated receptor-alpha.
Early pregnancy loss was independent of PPARalpha expression and PFOA induced postnatal lethality and expression of one copy of the gene was sufficient to mediate this effect, although other mechanisms may contribute.
Activation of mouse and human peroxisome proliferator-activated receptor alpha by perfluoroalkyl acids of different functional groups and chain lengths.
- C. Wolf, Margy L. Takacs, J. Schmid, C. Lau, B. Abbott
- Biology, ChemistryToxicological Sciences
- 1 November 2008
It is concluded that PFAAs of increasing carbon backbone chain lengths induce increasing activity of the mouse and human PPARalpha with a few exceptions, and PFAA carboxylates are stronger activators of mouse andhuman PPAR alpha than PFAA sulfonates.
Developmental toxicity of perfluorooctanoic acid in the CD-1 mouse after cross-foster and restricted gestational exposures.
The postnatal developmental effects of PFOA are due to gestational exposure and exposure earlier in gestation produced stronger responses, but further study is needed to determine if this is a function of higher total dose or if there is a developmentally sensitive period.
Comparative Hepatic Effects of Perfluorooctanoic Acid and WY 14,643 in PPAR-α Knockout and Wild-type Mice
It is suggested that PPAR-α is required for WY- and PFOA-induced cellular alterations in WT mouse liver, and Hepatic enlargement observed in KO mice may be due to an accumulation of cytoplasmic vacuoles that contain P FOA.
Activation of mouse and human peroxisome proliferator-activated receptors (alpha, beta/delta, gamma) by perfluorooctanoic acid and perfluorooctane sulfonate.
- Margy L. Takacs, B. Abbott
- BiologyToxicological Sciences
- 2007
The dose response and differential activation of mouse and human PPARalpha, beta/delta, gamma by PFOA and PFOS is characterized and is not necessarily predictive of a toxicological response in vivo.
Activation of Mouse and Human Peroxisome Proliferator-Activated Receptors ( , / , ) by Perfluorooctanoic Acid and Perfluorooctane Sulfonate
- Margy L. Takacs, B. Abbott
- Biology
- 2006
The dose response and differential activation of mouse and human PPARa, b/d, g by PFOA and PFOS is characterized.
Adverse reproductive outcomes in the transgenic Ah receptor-deficient mouse.
- B. Abbott, J. Schmid, J. Diliberto
- BiologyToxicology and Applied Pharmacology
- 15 February 1999
Investigation of the diverse biological responses mediated by the AHR led to production of a transgenic mouse in which the gene coding for the AhR was inactivated, and reproductive success was adversely affected in Ahr-null females and conceptuses.
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