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Structure-based and ligand-based virtual screening of novel methyltransferase inhibitors of the dengue virus
tl;dr
We discovered several potential compounds that are active against dengue virus NS5 MTase through virtual screening using structure-based and ligand-based methods. Expand
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An improved method for the preparations of nanostructured lipid carriers containing heat-sensitive bioactives.
Heat-sensitive bioactive compounds such as β-carotene and tocols, are widely used in the pharmaceutical and cosmetic fields. Their chemical stability in delivery systems is one of the major concernsExpand
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  • Open Access
Geraniin extracted from the rind of Nephelium lappaceum binds to dengue virus type-2 envelope protein and inhibits early stage of virus replication
BackgroundThe rapid rise and spread in dengue cases, together with the unavailability of safe vaccines and effective antiviral drugs, warrant the need to discover and develop novel anti-dengueExpand
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  • Open Access
Characterization of bovine serum albumin partitioning behaviors in polymer-salt aqueous two-phase systems.
In this paper, a linear relationship is proposed relating the natural logarithm of partition coefficient, ln K for protein partitioning in poly (ethylene glycol) (PEG)-phosphate aqueous two-phaseExpand
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Optimized enzymatic synthesis of levulinate ester in solvent-free system
Ethyl levulinate, produced through esterification of levulinic acid, is a ketoester with various applications. Synthesis of ethyl levulinate was carried out in solvent-free system using immobilizedExpand
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  • Open Access
Discovery of a new class of inhibitors for the protein arginine deiminase type 4 (PAD4) by structure-based virtual screening
tl;dr
We discovered three compounds as potential inhibitors of PAD4 by structure-based virtual screening using LIDAEUS. Expand
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  • Open Access
CPB1 of Aedes aegypti Interacts with DENV2 E Protein and Regulates Intracellular Viral Accumulation and Release from Midgut Cells
Aedes aegypti is a principal vector responsible for the transmission of dengue viruses (DENV). To date, vector control remains the key option for dengue disease management. To develop new vectorExpand
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  • Open Access
Testing of glyceryl monoesters for their anti-microbial susceptibility and their influence in emulsions.
Natural anti-microbial agents have received great attention in the cosmetic preservation area due to their well-documented safety profile. The anti-microbial activities of palm-based glycerylExpand
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  • Open Access
ICAM‐1 Peptide Inhibitors of T‐cell Adhesion bind to the allosteric site of LFA‐1. An NMR Characterization
We have used nuclear magnetic resonance to characterize the binding site of two intercellular adhesion molecule‐1 derived cyclic peptides, cIBC and cIBR, to the I‐domain of leukocyteExpand
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Bioassay-guided identification of an anti-inflammatory prenylated acylphloroglucinol from Melicope ptelefolia and molecular insights into its interaction with 5-lipoxygenase.
A bioassay-guided investigation of Melicope ptelefolia Champ ex Benth (Rutaceae) resulted in the identification of an acyphloroglucinol, 2,4,6-trihydroxy-3-geranylacetophenone or tHGA, as the activeExpand
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