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Oxidative Stress and Oxidative Damage in Carcinogenesis
TLDR
Evidence demonstrates an association between a number of single nucleotide polymorphisms in oxidative DNA repair genes and antioxidant genes with human cancer susceptibility and the resultant altered gene expression patterns evoked by ROS contribute to the carcinogenesis process. Expand
The adaptor molecule Disabled‐2 links the transforming growth factor β receptors to the Smad pathway
TLDR
Exposure of wild‐type Dab2 in a TGFβ‐signaling mutant restores TGF β‐mediated Smad2 phosphorylation, Smad translocation to the nucleus and Smad‐dependent transcriptional responses, suggesting that Dab1 is part of a multiprotein signaling complex. Expand
TGF‐β induces fibronectin synthesis through a c‐Jun N‐terminal kinase‐dependent, Smad4‐independent pathway
TLDR
It is shown that c‐Jun N‐terminal kinase (JNK), a member of the MAP kinase family, is activated in response to TGF‐β in the human fibrosarcoma HT1080‐derived cell line BAHgpt, and it is demonstrated that TGF•β‐mediated fibronectin induction requires activation of JNK which in turn modulates the activity of c‐ Jun and ATF‐2 in a Smad4independent manner. Expand
Regulation of the Wnt signaling pathway by disabled‐2 (Dab2)
TLDR
It is proposed that Dab2 functions as a negative regulator of canonical Wnt signaling by stabilizing the β‐catenin degradation complex, which may contribute to its proposed role as a tumor suppressor. Expand
Thioltransferase in human red blood cells: kinetics and equilibrium.
TLDR
Two substrate kinetic studies of HRBC TTase and rat liver TTase gave patterns of intersecting lines on double-reciprocal plots, indicating a sequential mechanism for the TTase reactions, rather than a ping-pong mechanism. Expand
Identification of nuclear beta II protein kinase C as a mitotic lamin kinase.
TLDR
Investigation of the involvement of two proposed human mitotic lamin kinases, beta II protein kinase C (PKC) and p34cdc2/cyclin B kinase, in human lamin B1 phosphorylation in vitro and in intact cells finds that both kinases can phosphorylate purified soluble lamination B at similar rates. Expand
Disabled-2 (Dab2) Mediates Transforming Growth Factor β (TGFβ)-stimulated Fibronectin Synthesis through TGFβ-activated Kinase 1 and Activation of the JNK Pathway*
TLDR
It is shown that the cytosolic adaptor protein disabled-2 (Dab2) directly stimulates JNK activity, whereas stable small interfering RNA-mediated ablation of Dab2 in NIH3T3 mouse fibroblasts and A10 rat aortic smooth muscle cells demonstrates that its expression is required for TGFβ-mediated FN induction. Expand
Wnt Signaling: Physiology and Pathology
TLDR
This work considers molecular defects in Wnt signaling components known to promote uncontrolled cell growth following induction of Wnt signalling and focuses on two recently identified factors, that seem to act as WNT signaling antagonists. Expand
Mode of Action analysis of perfluorooctanoic acid (PFOA) tumorigenicity and Human Relevance.
TLDR
This review will address the rodent (rat) cancer data and cancer Mode of Action of PFOA for tumors of the liver, testes and pancreas for tumor induction in rats following chronic dietary administration. Expand
TGF-beta suppresses IFN-gamma induction of class II MHC gene expression by inhibiting class II transactivator messenger RNA expression.
TLDR
Evidence is provided that TGF-beta suppresses IFN-gamma-induced class II MHC expression by inhibiting accumulation of CIITA mRNA. Expand
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