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Characterization of the β‐adrenoceptor subtype involved in mediation of glucose transport in L6 cells
The receptor that mediates the increase in glucose transport (GT) in response to β‐adrenoceptor (β‐AR) agonists was characterized in the rat skeletal muscle cell line L6, using theExpand
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Quantification of Functional Selectivity at the Human α1A-Adrenoceptor
Although G protein-coupled receptors are often categorized in terms of their primary coupling to a given type of Gα protein subunit, it is now well established that many show promiscuous coupling andExpand
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Desensitization of cardiac beta-adrenoceptor signaling with heart failure produced by myocardial infarction in the rat. Evidence for the role of Gi but not Gs or phosphorylating proteins.
This study examined mechanisms of beta-adrenergic (AR) desensitization in a myocardial infarction (MI) model of heart failure in the rat. Inotropic responses to isoproterenol (non-selective beta-ARExpand
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Structure and chromosomal localization of the human renal kallikrein gene.
Glandular kallikreins are a family of proteases encoded by a variable number of genes in different mammalian species. In all species examined, however, one particular kallikrein is functionallyExpand
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Mouse glandular kallikrein genes: identification and characterization of the genes encoding the epidermal growth factor binding proteins.
Previously, three proteins have been separately identified as the mouse epidermal growth factor binding protein (EGF-BP). We have identified and sequenced the coding regions of three distinct genesExpand
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Ligand‐directed signalling at β‐adrenoceptors
β‐Adrenoceptors (ARs) classically mediate responses to the endogenous ligands adrenaline and noradrenaline by coupling to Gsα and stimulating cAMP production; however, drugs designed as β‐AR agonistsExpand
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The Concise Guide to PHARMACOLOGY 2013/14: Overview
The Concise Guide to PHARMACOLOGY 2013/14 provides concise overviews of the key properties of over 2000 human drug targets with their pharmacology, plus links to an open access knowledgebase of drugExpand
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Characterization of β‐adrenoceptor mediated smooth muscle relaxation and the detection of mRNA for β1‐, β2‐ and β3‐adrenoceptors in rat ileum
Functional and molecular approaches were used to characterize the β‐AR subtypes mediating relaxation of rat ileal smooth muscle. In functional studies, (−)‐isoprenaline relaxation was unchanged byExpand
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Multiple signalling pathways involved in β2‐adrenoceptor‐mediated glucose uptake in rat skeletal muscle cells
β‐adrenoceptor (AR) agonists increase 2‐deoxy‐[3H]‐D‐glucose uptake (GU) via β2‐AR in rat L6 cells. The β‐AR agonists, zinterol (β2‐AR) and (−)‐isoprenaline, increased cAMP accumulation in aExpand
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Alternative splicing generates two isoforms of the β3‐adrenoceptor which are differentially expressed in mouse tissues
The β3‐adrenoceptor (AR) differs from the β1‐AR and β2‐ARs in having introns within and downstream of the coding block. This study demonstrates two splice variants of the mouse β3‐AR which differExpand
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