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ATM and ATR Substrate Analysis Reveals Extensive Protein Networks Responsive to DNA Damage
Cellular responses to DNA damage are mediated by a number of protein kinases, including ATM (ataxia telangiectasia mutated) and ATR (ATM and Rad3-related). The outlines of the signal transductionExpand
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Identification of the FANCI Protein, a Monoubiquitinated FANCD2 Paralog Required for DNA Repair
Fanconi anemia (FA) is a developmental and cancer-predisposition syndrome caused by mutations in genes controlling DNA interstrand crosslink repair. Several FA proteins form a ubiquitin ligase thatExpand
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Abraxas and RAP80 Form a BRCA1 Protein Complex Required for the DNA Damage Response
The BRCT repeats of the breast and ovarian cancer predisposition protein BRCA1 are essential for tumor suppression. Phosphopeptide affinity proteomic analysis identified a protein, Abraxas, thatExpand
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Tumor-promoting phorbol esters and activated Ras inactivate the tuberous sclerosis tumor suppressor complex via p90 ribosomal S6 kinase.
Tuberous sclerosis complex (TSC) is a genetic disorder caused by mutations in either of the two tumor suppressor genes TSC1 or TSC2, which encode hamartin and tuberin, respectively. Tuberin andExpand
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mTOR and S6K1 Mediate Assembly of the Translation Preinitiation Complex through Dynamic Protein Interchange and Ordered Phosphorylation Events
In response to nutrients, energy sufficiency, hormones, and mitogenic agents, S6K1 phosphorylates several targets linked to translation. However, the molecular mechanisms whereby S6K1 is activated,Expand
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The Chlamydomonas reinhardtii BBSome is an IFT cargo required for export of specific signaling proteins from flagella
The Bardet-Biedl syndrome protein complex (BBSome) is a cargo adapter rather than an essential part of the intraflagellar transport (IFT) machinery.
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Fyn Tyrosine Kinase Is a Critical Regulator of Disabled-1 during Brain Development
BACKGROUND Disabled-1 (Dab1) is an intracellular adaptor protein that regulates migrations of various classes of neurons during mammalian brain development. Dab1 function depends on its tyrosineExpand
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Molecular mechanisms mediating mammalian mitogen-activated protein kinase (MAPK) kinase (MEK)-MAPK cell survival signals.
Introduction To maximize advantages and reduce costs associated with life as an interdependent community of cells, multicellular organisms have evolved common mechanisms to regulate the life andExpand
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SKAR Is a Specific Target of S6 Kinase 1 in Cell Growth Control
BACKGROUND The mammalian target of rapamycin (mTOR) and phosphatidylinositol 3-kinase (PI3K) signaling pathways promote cell growth and cell cycle progression in response to nutritional, energy, andExpand
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Rsk1 mediates a MEK–MAP kinase cell survival signal
BACKGROUND Growth factors activate an array of cell survival signaling pathways. Mitogen-activated protein (MAP) kinases transduce signals emanating from their upstream activators MAP kinase kinasesExpand
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