B V Kamdar

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A simple, one-step chemical oxidation of triazolam (7) to its 4-hydroxy analogue, 7a, has been developed and applied to other triazolo- and imidazobenzodiazepines. The reaction may be used to convert diazepam to temazepam. 4-Hydroxytriazolo[4,3-a][1,4]benzodiazepines have low central nervous system sedative and anticonvulsant activity in sharp contrast to(More)
A series of novel spirocyclic benzopyran imidazolones were synthesized as rigid analogues of cromakalim. These compounds cause a dose-dependent membrane hyperpolarization of A10 rat aorta cells. This hyperpolarization was blocked by pretreatment with glyburide, indicating that the spirocyclic benzopyran imidazolones were acting by increasing the open(More)
High Peak to Average Power Ratio (PAPR) is one of the major challenges of any Orthogonal Frequency Division Multiplexing (OFDM) system. Many methods have been suggested for reducing PAPR. In this paper we design and implement an OFDM system on a FPGA along with PAPR reduction using Selected Mapping (SLM) technique. We analyse challenges in practical(More)
The synthesis and in vitro renin inhibitory potencies of angiotensinogen (ANG) analogues having amide (CONH) bond replacements at P1-P1', the Leu-Val cleavage site, corresponding to Leu psi[CH2SO]Val, and the trans olefinic analogue of statine (Sta), 4(S)-amino-6-methyl-2(E)-heptenoic acid (dehydrostatine, Dhs), are reported. These are compared to P1-P1'(More)
A family of 7-(trifluoromethyl)-4-aminoquinolines that are hypotensive agents and that act by a novel sympatholytic mechanism is described. Structure-activity relationships in this series have been elucidated. Some of the more potent hypotensives were evaluated for safety in the mouse. A candidate, 1-[(4-fluorophenyl)sulfonyl]-4-[4-[[7-(trifluoromethyl)-4-(More)
This paper describes a design and implementation of a baseband Orthogonal Frequency Division Multiplexing (OFDM) transceiver utilizing Multiple Input Multiple Output (MIMO) signal processing for increased data rate. MIMO OFDM has many promising features which allow wireless devices to communicate at a higher data rate with reduced errors and hardware(More)
A series of 1-[1-(3,4-dimethoxy-1H-2-benzopyran-1-yl)alkyl]-4-arylpiperazines that shows hypotensive activity in the conscious rat has been investigated. Structure-activity relationships are described. A typical example that was investigated in greater detail is 1-[2-(3,4-dihydro-6,7-dimethoxy-1H-2-benzopyran-1-yl)ethyl]-4-(4-fluorophenyl)piperazine. This(More)
In this paper we implemented real time speech processing and recognition using Infinite Impulse Response (IIR) digital filters. We used an array of 7 digital bandpass filters to filter out various frequencies and recognize each word by its frequency spectra. The system is implemented on a low cost AVR architecture microcontroller which also explored the use(More)