Learn More
Frameworks and design patterns are emerging technologies in software engineering. They increase software quality in terms of reusability, modularity and extensibility. Synchronous groupware can benefit of these new technologies. This article describes AMF-C, a multiagent model which structures each agent with a various number of facets, and two associated(More)
The present study used quantitative volume estimates of the hippocampus based on structural magnetic resonance imaging (MRI) to predict memory performance of individuals with epilepsy of temporal lobe origin (TLE). Twenty individuals with TLE completed standardized neuropsychological tests and a quality of life inventory, and participated in a brain MRI(More)
Toll-like receptors (TLRs) mediate the induction of the innate immune system in response to pathogens, injury and disease. However, they also play non-immune roles and are expressed in the central nervous system (CNS) during prenatal and postnatal stages including adulthood. Little is known about their roles in the CNS in the absence of pathology. Several(More)
Spinal cord injury (SCI) affects motor, sensory, and autonomic functions. As current therapies do not adequately alleviate functional deficits, the development of new and more effective approaches is of critical importance. Our earlier investigations indicated that intrathecal administration of a toll-like receptor 9 (TLR9) antagonist,(More)
Epidemiological studies have associated infection during pregnancy with increased risk of neurodevelopmental disorders in children, which is modeled in rodents by stimulating the immune system of pregnant dams with microorganisms or their mimics, such as poly(I:C) or LPS. In two prenatal mouse models, we show that in utero exposure of the fetus to(More)
INTRODUCTION An appropriate architectural model should fulfill three main objectives. Firstly, it organizes software structure to improve implementation, portability and maintenance. Secondly, it helps identify the functional components (e.g. MVC [1]), which is essential during analysis and design process. Its third role is to help the understanding of a(More)
Loss of bladder function is an important consequence of a spinal cord injury (SCI) but is rarely assessed in animal studies of SCI. Here, we use a simple outcome measure (volume of retained urine) to assess bladder dysfunction over time following moderate contusion injuries at 3 different thoracic levels (T1, T4, or T9) and complete crush injuries (T1 vs.(More)
Toll-like receptors (TLRs) are mediators of the innate immune response to exogenous pathogens. They have also been implicated in sterile inflammation associated with systemic injury and non-infectious diseases via binding of endogenous ligands, possibly released by damaged cells. Emerging evidence indicates that some TLRs play a role in nervous system(More)
This paper discusses the advantages of an integrated approach to computer-aided design and more particularly to computer-aided architectural design (CAAD). We have studied different ways of organizing integrated systems, and our work has enabled us to define an integrated system for computer-aided architectural design: SIGMA-ARCHI which we describe. This(More)
  • 1