B. Suman Bharathi

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OBJECTIVE Multiple sclerosis (MS) is considered a chronic inflammatory and demyelinating disease of the central nervous system. Evidence that axonal and neuronal pathology contributes to the disease is accumulating, however, the distribution of neuronal injury as well as the underlying mechanisms have not yet been fully clarified. Here, we investigated the(More)
During development, axonal projections have a remarkable ability to innervate correct dendritic subcompartments of their target neurons and to form regular neuronal circuits. Altered axonal targeting with formation of synapses on inappropriate neurons may result in neurodevelopmental sequelae, leading to psychiatric disorders. Here we show that altering the(More)
Selenium exerts many, if not most, of its physiological functions as a selenocysteine moiety in proteins. Selenoproteins are involved in many biochemical processes including regulation of cellular redox state, calcium homeostasis, protein biosynthesis, and degradation. A neurodevelopmental syndrome called progressive cerebello-cortical atrophy (PCCA) is(More)
Biomedical systems involve complex interactions between diverse components. Problem solving in such systems requires insight, i.e. the capability to make non-obvious connections. In this paper, we present a game-based problem solving environment, where users can explore biological interactions with navigation on atomic to macroscopic scales, role-play, and(More)
Understanding and solving biomedical problems requires insight into the complex interactions between the components of biomedical systems by domain and non-domain experts. This is challenging because of the enormous amount of data and knowledge in this domain. Therefore, non-traditional educational tools have been developed such as a biological storytelling(More)
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