B. Shah

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A novel therapy is demonstrated utilizing magnetic nanoparticles for the dual purpose of delivering microRNA and inducing magnetic hyperthermia. In particular, the combination of lethal-7a microRNA (let-7a), which targets a number of the survival pathways that typically limit the effectiveness of hyperthermia, with magnetic hyperthermia greatly enhances(More)
Multiple dysregulated pathways in tumors necessitate targeting multiple oncogenic elements by combining orthogonal therapeutic moieties like short-interfering RNAs (siRNA) and drug molecules in order to achieve a synergistic therapeutic effect. In this manuscript, we describe the synthesis of cyclodextrin-modified dendritic polyamines (DexAMs) and their(More)
Stimuli-responsive drug delivery vehicles have garnered immense interest in recent years due to unparalleled progress made in material science and nanomedicine. However, the development of stimuli-responsive devices with integrated real-time monitoring capabilities is still in its nascent stage because of the limitations of imaging modalities. In this(More)
Mitochondria-targeting peptides have garnered immense interest as potential chemotherapeutics in recent years. However, there is a clear need to develop strategies to overcome the critical limitations of peptides, such as poor solubility and the lack of target specificity, which impede their clinical applications. To this end, we report magnetic core-shell(More)
We describe the development of a versatile fluorescence resonance energy transfer (FRET)-based real-time monitoring system, consisting of (a) coumarin-labeled-cysteine tethered mesoporous silica nanoparticles (MSNs) as the drug carrier, (b) a fluorescein isothiocyanate-β-cyclodextrin (FITC-β-CD) as redox-responsive molecular valve blocking the pores, and(More)
An effective therapeutic approach against cancer typically requires the combination of several modalities, such as chem-otherapy, radiation, and hyperthermia. In this regard, the development of multifunctional nanomaterial-based systems with combined therapeutic and molecular imaging capabilities has shown great potential but has not been fully explored. In(More)
T he outstanding progress made in fundamental cancer biology over the past decades has not yet fully translated into comparable clinical advances. This has been mainly attributed to inadequacies of approaches available to administer the therapeutics moieties, such that they will reach the target tumor site in their most potent form with minimal collateral(More)
A 52-year-old male with a history of recurrent deep venous thrombosis underwent a CT scan of the chest investigating a suspected pulmonary embolism. The scan revealed thickening of the splenic flexure with foci of air adjacent to the colon (Figure 1). The patient reported mild nausea and chronic intermittent hemorrhoidal bleeding without abdominal pain.(More)