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Reversible valproic acid-induced dementia was documented in a 21-year-old man with epilepsy who had a 3-year history of insidious progressive decline in global cognitive abilities documented by serial neuropsychological studies. Repeat neuropsychological testing 7 weeks after discontinuation of the drug revealed dramatic improvement in IQ, memory, naming,… (More)
Valproic acid (VPA) consistently and reproducibly elevates arterial ammonia in rats injected with an amino acid load. The extent of the hyperammonemia is dependent on the dose of VPA injected or VPA plasma concentration and the amino acid dose. Bilaterally nephrectomized rats injected with VPA and an amino acid load also develop hyperammonemia, which… (More)
Three adults on unrestricted protein diets receiving valproic aci (VPA) developed gastrointestinal symptoms with encephalopathy and/or deteriorating seizure control associated with arterial hyperammonemia and normal liver function tests. The signs and symptoms did not directly correlate with VPA dosage and the arterial ammonium levels did not correlate with… (More)
Concurrent burst suppression and alpha pattern coma developed in the EEG of a 2-year-old child who suffered a cardiac arrest secondary to hypoxemia from Haemophilus influenza epiglottis. The neurophysiological implications of this association are discussed and the literature pertaining to the role of barbiturates in the production of post-anoxic coma with… (More)
We describe a man who developed a gliosarcoma at the site of a previously surgically decompressed frontal Actinomyces israelii brain abscess. We review the clinical profile of gliosarcoma and the possible role of the abscess and operation in the induction of this malignancy.
Activity occurring predominantly at or circumscribed to the midline electrodes Fz, Cz and Pz was examined in 18 neurologically normal neonates of 27-42 weeks conceptional age (CA). Admixtures of delta and beta activity, which sometimes resembled delta brushes and rhythmical theta activity, of less than three seconds duration were seen during the suppressed… (More)
Lightning streaks of Moore are recurrent stereotypic vertical visual phenomena that must be distinguished from similar symptoms due to retinal ischemia, optic disk abnormalities, or mechanical retinal or optic nerve stimulation. These brief flashes are oriented vertically and are perceived in the temporal visual field after eye movement. Senescent posterior… (More)