B. Rodriguez

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In this paper, we illustrate how advanced computational modelling and simulation can be used to investigate drug-induced effects on cardiac electrophysiology and on specific biomarkers of pro-arrhythmic risk. To do so, we first perform a thorough literature review of proposed arrhythmic risk biomarkers from the ionic to the electrocardiogram levels. The(More)
BACKGROUND Increased spatial dispersion of restitution properties has been associated to arrhythmic risk. An ECG-based index quantifying restitution dispersion, DRest, is evaluated in patients who experienced Torsades de Pointes (TdP) under sotalol challenge and compared with the response in healthy subjects. METHODS AND RESULTS ECG recordings were(More)
In this paper, we present a method for diagnosing gate delay faults in synchronous sequential circuits. This method is an outgrowth of our previous work on delay fault diagnosis in combinational circuits, and is therefore based on a path tracing algorithm appropriate for sequential circuits. Input data for diagnosis are (1) the gate level description of the(More)
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