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MicroRNAs (miRNAs) are small, non-coding RNAs that regulate gene expression and play a critical role in development, homeostasis, and disease. Despite their demonstrated roles in age-associated pathologies, little is known about the role of miRNAs in human aging and longevity. We employed massively parallel sequencing technology to identify miRNAs expressed(More)
Unrepaired or misrepaired DNA damage has been implicated as a causal factor in cancer and aging. Xpd(TTD) mice, harboring defects in nucleotide excision repair and transcription due to a mutation in the Xpd gene (R722W), display severe symptoms of premature aging but have a reduced incidence of cancer. To gain further insight into the molecular basis of the(More)
1 Abstract This paper presents a technique for the classiication and analysis of seabed sediments from sidescan sonar image, the origins of which lie in the body of fractal theory. Six seabed types were analysed, namely clay, mud, sand, gravel, stones and rock. These data sets have previously been analysed by several authors who have used techniques based(More)
A high-resolution multibeam survey of the northwest Florida shelf mapped six relict shelf-edge deltas, each with a drowned barrier–island system developed on its south and southwestern rims. The deltas appear to have formed during periods of sea-level stasis that occurred between 58,000 and 28,000 years ago. The barrier islands formed on the deltas during(More)