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MicroRNAs (miRNAs) are small, non-coding RNAs that regulate gene expression and play a critical role in development, homeostasis, and disease. Despite their demonstrated roles in age-associated pathologies, little is known about the role of miRNAs in human aging and longevity. We employed massively parallel sequencing technology to identify miRNAs expressed(More)
Unrepaired or misrepaired DNA damage has been implicated as a causal factor in cancer and aging. Xpd(TTD) mice, harboring defects in nucleotide excision repair and transcription due to a mutation in the Xpd gene (R722W), display severe symptoms of premature aging but have a reduced incidence of cancer. To gain further insight into the molecular basis of the(More)
We consider the problem of detecting discrete objects in sidescan SONAR, utilising the geometric and statistical properties of the objects expressed in a Bayesian framework. The model proposed hypothesises that the observed image is formed through observations of a simple texturing process, modiied to incorporate the presence of potential objects. Suitable(More)