B Michele Melia

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PURPOSE To evaluate the extent of neural cell death in eyes with disciform age-related macular degeneration. METHODS Six eyes with disciform degeneration at various stages and five age-matched control eyes were selected for morphometric analysis using digitized light microscopic images. Disciform scars were classified as subneurosensory retinal,(More)
PURPOSE To report data on the response of previously untreated strabismic amblyopia to spectacle correction. DESIGN Prospective, interventional case series. METHODS Twelve patients with previously untreated strabismic amblyopia were prescribed spectacles and examined at five-week intervals until visual acuity was not improved from the prior visit. (More)
A novel paired-like homeobox gene, designated as Qrx, was identified by a yeast one-hybrid screen using the bovine Rhodopsin promoter Ret-1 DNA regulatory element as bait. Qrx is preferentially expressed in both the outer and inner nuclear layers of the retina. Its homeodomain is nearly identical to that of Rx/Rax, a transcription factor that is essential(More)
OBJECTIVES To determine the central corneal thickness (CCT) in healthy white, African American, and Hispanic children from birth to 17 years of age and to determine whether CCT varies by age, race, or ethnicity. DESIGN Prospective observational multicenter study. Central corneal thickness was measured with a handheld contact pachymeter. RESULTS A total(More)
PURPOSE To describe, in a group of patients with moderately advanced retinitis pigmentosa (RP), the prevalence of cystoid macular edema (CME), the variation in foveal thickness over a 48-week period, the correlation of visual acuity (VA) with retinal thickness, and the lack of response of CME to lutein administration. METHODS Optical coherence tomography(More)
OBJECTIVE To report visual acuity during the first three years after iodine 125 (I(125)) brachytherapy for medium-sized choroidal melanoma and to identify important baseline and treatment factors associated with posttreatment visual acuity in a group of patients who were treated and observed prospectively as part of a large, randomized clinical trial. (More)
OBJECTIVE To measure limitations in the daily activities of village life associated with having trichiasis for individuals with and without visual acuity loss. METHODS Men and women 40 years and older in 6 randomly chosen rural villages in the Kongwa district of Tanzania had visual acuity measured and were examined by an ophthalmologist. Subjects(More)
PURPOSE To assess the internal consistency of a short, widely-used health-related quality of life instrument in patients with choroidal melanoma, its appropriateness for use in a large clinical trial in patients with that disease, and the feasibility of various methods of instrument administration. METHODS The SF-36 was administered to 31 choroidal(More)
PURPOSE To evaluate the extent of neural cell death in eyes with geographic atrophy (GA). METHODS Ten eyes with GA and five age-matched control eyes were selected for morphometric analysis. The nuclei of the ganglion cell, inner nuclear, and outer nuclear layers were counted in contiguous 100-microm segments from 1,500 microm nasal to 1,500 microm(More)
OBJECTIVE To determine visual acuity improvement in children with strabismic and combined strabismic-anisometropic (combined-mechanism) amblyopia treated with optical correction alone and to explore factors associated with improvement. DESIGN Prospective, multicenter, cohort study. PARTICIPANTS We included 146 children 3 to <7 years old with previously(More)