B. M. Peake

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This review summarizes direct and indirect analytical methods for the detection and quantification of the reactive oxygen species (ROS): 1O2, O 2 ·− /HOO·, H2O2, HO·, and CO 3 ·− in aqueous solution. Each section briefly describes the chemical properties of a specific ROS followed by a table (organized alphabetically by detection method, i.e., absorbance,(More)
An equilibrium model based on the CO 2 system was developed to model pH throughout the estuarine salinity range using the composition of the river and seawater end members. In order to validate the model, a spectrophotometric method was used to measure pH in an estuary and laboratory mixing experiments. The model successfully represented the measured pH(More)
The effects of ethanol on the conformation of proteins or fluidity of lipids was studied in human erythrocyte ghosts and rat brain synaptosomal membranes. A maleimide nitroxide probe (MAL-6) was coupled to membrane protein, or 5-doxylstearic (5NS) was dissolved in the membrane lipid, and the electron spin resonance (ESR) spectra were recorded in the(More)
Domoic acid and its isomers are produced via algal blooms and are found in high concentrations in shellfish. Here, we assessed the acute seizurogenic potencies of isomers-D, -E and -F and their binding affinities at heterogeneous populations of KA receptors from rat cerebrum. In addition, binding affinities of all six isomers (Iso-A through -F) were(More)
The tricarboxylic neurotoxin domoic acid (DA) binds trace metals such as iron and copper. In vitro brain slice recording (area CA1 of rat hippocampal slices) was used to assess changes in DA potency in the presence of cadmium and zinc. Cadmium or zinc alone had little or no effect on CA1 responses. DA alone produced hyperexcitability and, with prolonged(More)
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