B. M. Kogan

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The content of catecholamines and their metabolites in the brain and the relationship between cerebral catecholamine levels and their urinary excretion were studied in rats with 6-OHDA-induced hemiparkinsonism. 6-OHDA reduced brain concentrations of dopamine, DOPAC, and homovanilic acid and urinary excretion of dopamine, dioxyphenilalanine, and DOPAC by(More)
Basal activities of adenylate cyclase and guanylate cyclase were determined in lymphocytes and platelets of alcoholics with different severity of alcoholic withdrawal syndrome. Compared to controls, significant changes were found in the basal activities of adenylate and guanylate cyclase in all groups of patients. Adenylate cyclase activity in lymphocytes(More)
Dopamine content of blood, activity of adenylate- and guanylate cyclases in platelets and lymphocytes, catechol-O-methyltransferase in erythrocytes, dopamine-beta-hydroxylase in blood plasma, monoamine oxidase in platelets, cAMP and cGMP content of blood, and the intensity of 3H-DA uptake by platelets have been investigated in alcoholic patients at(More)
42 persons which commited crime sexual actions were examined in terms of clinical and neurochemical investigations. The sexual behaviours of 31 patients from this group were associated with sexual inclination pathology--with paraphilia. The patients were divided into 2 groups namely with compulsive form of paraphilia (13 individuals) and without compulsive(More)
It is shown that the platelet serotonin level and the maximum rate of uptake of labeled serotonin by platelets in the groups of patients with anxious-depressive and depressive-hysterical syndromes is markedly higher than in the control (patients with psychopathy without signs of depression) and in the group with the asthenodepressive syndrome. In all groups(More)
The effect of sulfated octapeptide of cholecystokinin (CCK) on dopamine turnover was examined in different parts of the rat brain. It was demonstrated that CCK administered intrapeutoneally in doses of 5, 15 and 30 micrograms/kg significantly increased dopamine turnover in the amygdala, and nucleus accumbeus, without changing dopamine turnover in the(More)
The concept of the principal unity of the pivotal mechanisms underlying the formation of the syndrome of dependence on alcohol and various narcotic agents is presented. The central link of the mechanisms is the totality of the specific disturbances of neurochemical processes among which of particular importance are the specific changes in the functional(More)