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Experiments were designed to determine how cold-induced vasoconstriction is mediated in superficial vessels of human finger skin. alpha-Adrenoceptor antagonists were administered into the finger skin by iontophoresis, and local cooling was applied by a laser-Doppler probe supplied with Peltier elements. Cold-induced vasoconstriction was abolished after(More)
Experiments were designed to study adrenoceptor function in subjects with Raynaud's disease. Sympathetic agonists and antagonists were administered into the finger skin by iontophoresis, and the resulting change in local skin blood flow was evaluated by laser Doppler technique. The effects of norepinephrine (NE, stimulating alpha 1- and alpha(More)
To study afferent pain and efferent sympathetic nerve function in vibration-induced Raynaud's phenomenon, 10 patients and 11 healthy controls were examined. Thresholds for mechanically and thermally induced pain were determined on the left side of the tip of the second finger, on the skin fold between thumb and second finger and on the ear lobe. Superficial(More)
The aim of this study was to evaluate whether iontophoretic administration of the vasoactive agents noradrenaline (NA) and angiotensin (AII) combined with measurement of skin blood flow with a laser Doppler technique could serve as a predictive method for pre-eclampsia. Nine healthy non-pregnant women, 9 healthy pregnant women and 9 pre-eclamptic patients(More)
To study if obliterative lesions in digital arteries are relevant as the pathogenic factor in vibration white finger, finger blood flow was measured in 15 subjects with advanced symptoms and in 15 controls by venous occlusion plethysmography before and after vasodilation. Before vasodilation, the subjects had lower temperature, blood flow, and peak blood(More)
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