B. Leticia Rodriguez

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The initial edition of this book was published in 1974, as one of the first textbooks that tried to teach modern biochemistry with a clinical perspective. The recently revised fifth edition continues to be one of the few textbooks in biochemistry that focuses primarily on clinical aspects of biochemistry and thus remains a useful book for health science(More)
335 tional management. In addition, it mentions some of the extra-intestinal manifestations of IBD and therapy for them. Both historians and scientists campaign under the banner of objectivity in the academic search for truths. Their paths seldom cross-historians look back, scientists look in-but, in recent years, historians of science have begun to make(More)
BACKGROUND The present study was designed to evaluate the extent to which pretreatment with microneedles can enhance skin permeation of nanoparticles in vitro and in vivo. Permeation of live bacteria, which are physically nanoparticles or microparticles, through mouse skin pretreated with microneedles was also studied to evaluate the potential risk of(More)
Liposomes are biodegradable and can be used to deliver drugs at a much higher concentration in tumor tissues than in normal tissues. Both passive and active drug delivery by liposomal nanoparticles can significantly reduce the toxic side effects of anticancer drugs and enhance the therapeutic efficacy of the drugs delivered. Active liposomal targeting to(More)
Docetaxel (DCX) is a second generation taxane. It is approved by the U.S. Food and Drug Administration for the treatment of various types of cancer, including breast, non-small cell lung, and head and neck cancers. However, side effects, including those related to Tween 80, an excipient in current DCX formulations, can be severe. In the present study, we(More)
BACKGROUND Double stranded RNA (dsRNA) has multiple anti-tumor mechanisms. Over the past several decades, there have been numerous attempts to utilize synthetic dsRNA to control tumor growth in animal models and clinical trials. Recently, it became clear that intracellular dsRNA is more effective than extracellular dsRNA on promoting apoptosis and(More)
193 lectures and serve to make this volume something more than four unconnected lectures on assorted topics in neuroscience. Volume 4 in Fidia's series of neuroscience award lectures again honors four leading researchers in the tradition of pioneering Italian neuroscientists. As in Volume 3, the grouping of lectures in this volume is somewhat uneven,(More)