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A novel 15-subunit complex with the capacity to remodel the structure of chromatin, termed RSC, has been isolated from S. cerevisiae on the basis of homology to the SWI/SNF complex. At least three RSC subunits are related to SWI/SNF polypeptides: Sth1p, Rsc6p, and Rsc8p are significantly similar to Swi2/Snf2p, Swp73p, and Swi3p, respectively, and were(More)
The detection of a DNA double-strand break (DSB) is necessary to initiate DSB repair. Several proteins, including the MRX/N complex, Tel1/ATM (ataxia telangiectasia mutated), and Mec1/ATR (ATM and Rad3 related), have been proposed as sensors of DNA damage, yet how they recognize the breaks is poorly understood. DSBs occur in the context of chromatin,(More)
To date, two positron emission tomography (PET) studies have explored 5-HT(1A) receptor density in the hippocampus of Alzheimer's disease (AD) patients. They showed early changes of 5-HT(1A) receptors in this brain region, known to have a dense serotonergic innervation. These studies only reported measurements in hippocampus. In the present PET study, we(More)
INTRODUCTION Executive impairments seem to be an important characteristic of normal cognitive aging. This impairment can however affect elderly individuals in their daily living activities. Miyake et al.[Cogn Psychol 41 (2000) 49-100] showed that the executive system is made up of three particular components: the inhibition of irrelevant information, the(More)
We administered the Set Test to 128 control subjects and 82 patients with Alzheimer's disease. The subjects were to produce, within 15 seconds, items within specific categories: colors, animals, fruits and cities. Control subjects obtained a mean score of 40.3 +/- 3.6 and Alzheimer's disease patients a mean score of 2.7 +/- 4. We found a significant effect(More)
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