Postnatal exposure to lead or methyl mercury results in mental retardation, learning deficits, and other neurobehavioral effects in humans, and adverse consequences of prenatal exposure have been clearly documented with methyl mercury. To examine the developmental neurotoxicity of these metals, especially lead, concurrent schedules of food reinforcement… (More)
Timed-pregnant squirrel monkeys were exposed orally to lead during the last 1/2 to 2/3 of gestation such that maternal lead levels ranged from 21 to 70 micrograms/dl in blood. Offspring of these lead-exposed monkeys were compared to gender-matched, untreated controls (blood-lead levels from 4 to 9 micrograms/dl), born at about the same time. When the… (More)
Pregnant squirrel monkeys were exposed 5 days/week to mercury vapor at a concentration of 0.5 mg Hg/m3 air for 7 hr/day, or at 1 mg Hg/m3 air for 4 or 7 hr/day. The calculated total mercury absorption ranged between 0.8 and 5.4 mg (range of daily absorption 0.04-0.07 mg). The mercury concentration in the cerebral occipital lobe of the offspring ranged… (More)
OBJECTIVE To investigate the relationship between the prevalence of schizophrenia and measures of social deprivation in varying areas in the city of Malmö. METHOD A case-finding study of schizophrenia was combined with a victimization survey. Data was factor-analysed and visualized using geographical information system software. RESULTS The… (More)
Thirty-one squirrel monkey fetuses were exposed to lead acetate given to the mothers perorally during the last three-fourths or two-thirds of pregnancy. The mean maternal blood lead concentration of the group was 37 micrograms/100 ml and the individual means ranged from 22-82 micrograms/100 ml. Examination of the central nervous system was performed in 15… (More)
Morphometrical analysis of the frontal lobe neocortex of seven selected cases of mental retardation of unclassified aetiology and pathology, showing mild dysplastic changes of the neocortex on routine workup, were compared with nine normal controls and seven cases with Down's syndrome. In comparison with the normal controls, the group with 'unclassified'… (More)
This report describes 75 cases of reliable 1-2-hour surgical anesthesia of newborn to adult squirrel monkeys, with rapid induction and recovery, using a single intramuscular dose of alphaxolone-alphadolone (doses between 11.5 and 30 mg/kg body weight).