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Although the link between the BRCA1 tumour-suppressor gene and hereditary breast and ovarian cancer is established, the role, if any, of BRCA1 in non-familial cancers is unclear. BRCA1 mutations are rare in sporadic cancers, but loss of BRCA1 resulting from reduced expression or incorrect subcellular localization is postulated to be important in(More)
p53 mutations are the most common genetic alterations found in human malignancies. However current estimates of p53 alterations in cancers may be inaccurate because there is evidence that current approaches do not detect all p53 alterations. In this study we determine the status of the p53 gene by complete DNA sequencing of exons 2 through 11 as well as(More)
Selected abstracts submitted to the Third International Symposium on Hereditary Breast and Ovarian Cancer BRCA: Fifteen Years of Progress, Third International Symposium on Hereditary Breast and Ovarian Cancer; October 14–16, 2009; Centre Mont-royal, Montreal, Quebec, Canada The opinions expressed in the abstracts are those of the authors and are not to be(More)
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