B. K. Beznosko

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After a single injection of cholinergic neurotoxin ethylcholine aziridinium (AF64A, 3 nmol intracerebroventricularly (i.c.v.)), rats failed to perform the tasks in the active avoidance (learning and retention paradigms) and water maze tests. N-Acetylserotonin (NAS), melatonin and their newly synthesized derivatives, CA-15 and CA-18, (0.3-3.0 mg/kg daily for(More)
  • B. K. Beznosko, V. M. Usanova, +5 authors E. N. Tsvetkov
  • 2004
Propyldiphenylphosphine Oxide (IV). A 1.7 ml portion of a 56% KOH solution was added with stirring to a solution of 3.7 g of diphenylphosphonous acid in 15 ml of DMSO at 20=C after which 2.8 g of propyl bromide was added dropwise at 20-55~ The mixture was heated for 1 h at 40~ and diluted with 75 ml water at 20~ The precipitated oil was extracted with(More)
12. O. Kosian and M. Ferles, Coll. Czech~ Chem. Commun., 43, 1413 (1978). 13. R~ Levinsohn, Clin. Chim. Acta, 81, 247 (1977). 14. J. Litchfield and F. A. Wilcoxon, J. Pharmacol. Exp~ Ther., 96, 99 (1943). 15. J. Piechachek and H. Bojarska-Dahlig, Acta Prolon. Pharmo, 23, 7 (1966)o 16. S. Togashi and H. Yamada, US Pat~ No. 3,322,772 (1967); Chem. Abstr~ 7-1,(More)
The substitution of ether oxygen by a methylene group in the acetylcholine molecule sharply decreases the muscarinic action, while the substitution of the carbonyl group by a methylene one reduces the nicotinic properties. Sebacoyldicholine possesses only nicotinic properties. The replacement of its ether oxygens by methylene groups lowers the stimulant(More)
In anesthetized cats, whose peripheral muscarinic-cholinorecptors are blocked by m-cholinolytics (benzilyl choline) failing to penetrate into the brain, the cholinesterases reactivator diethyxime debars the centrally caused fall of the arterial pressure produced by armine, an inhibitor of cholinesterases readily gaining access into the brain. Diethyxime is(More)
New compounds representing derivatives of acyclic isothioureas have been synthesized, which are capable of simultaneously activating AMPA receptors and blocking NMDA receptors. In order to produce cognitive-stimulating effect, of principal importance is the pathway of NMDA receptor blockade produced by the drug. Positive influence is due to the blockade of(More)
The effect of derivatives of arachidonic and docosahexaenoic acids on AMPA receptors in Purkinje cells from the rat cerebellum was studied using the patch-clamp electrophysiological method. It was shown that derivatives of arachidonic acid-arachidonoyl dopamine and docosahexaenoic acid-docosahexaenoyl dopamine and ester of docosahexaenoic acid with ethylene(More)
It was shown for the first time that estrogens 17 beta- and 17 alpha-estradiols compensate impaired cognitive functions in rats with partial chronic deprivation of cholinergic functions in the central nervous system induced by intracerebral administration of selective cholinergic neurotoxin AF64A. 17 beta-Estradiol produced strong dose-dependent changes in(More)
  • B. K. Beznosko, V. M. Usanova, +4 authors E. N. Tsvetkov
  • 2006
As is known, 1,1-dimethyl-3-oxobutylphosphonic acid dimethyl ester (dimephosphon) exhibits antiinflammatory properties, although the mechanism of its action differs from that known in classical nonsteroidal drugs [1]. Recently we have demonstrated that some alkyldiphenylphosphin oxides possess antiinflananatory and/or analgesic properties [2]. The most(More)