B. K. Beznosko

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After a single injection of cholinergic neurotoxin ethylcholine aziridinium (AF64A, 3 nmol intracerebroventricularly (i.c.v.)), rats failed to perform the tasks in the active avoidance (learning and retention paradigms) and water maze tests. N-Acetylserotonin (NAS), melatonin and their newly synthesized derivatives, CA-15 and CA-18, (0.3-3.0 mg/kg daily for(More)
Propyldiphenylphosphine Oxide (IV). A 1.7 ml portion of a 56% KOH solution was added with stirring to a solution of 3.7 g of diphenylphosphonous acid in 15 ml of DMSO at 20=C after which 2.8 g of propyl bromide was added dropwise at 20-55~ The mixture was heated for 1 h at 40~ and diluted with 75 ml water at 20~ The precipitated oil was extracted with(More)
It was shown for the first time that estrogens 17β- and 17α-estradiols compensate impaired cognitive functions in rats with partial chronic deprivation of cholinergic functions in the central nervous system induced by intracerebral administration of selective cholinergic neurotoxin AF64A. 17β-Estradiol produced strong dose-dependent changes in the weights(More)
The effect of derivatives of arachidonic and docosahexaenoic acids on AMPA receptors in Purkinje cells from the rat cerebellum was studied using the patch-clamp electrophysiological method. It was shown that derivatives of arachidonic acid-arachidonoyl dopamine and docosahexaenoic acid-docosahexaenoyl dopamine and ester of docosahexaenoic acid with ethylene(More)
It was shown for the first time that estrogens 17 beta- and 17 alpha-estradiols compensate impaired cognitive functions in rats with partial chronic deprivation of cholinergic functions in the central nervous system induced by intracerebral administration of selective cholinergic neurotoxin AF64A. 17 beta-Estradiol produced strong dose-dependent changes in(More)
In anesthetized cats, whose peripheral muscarinic-cholinorecptors are blocked by m-cholinolytics (benzilyl choline) failing to penetrate into the brain, the cholinesterases reactivator diethyxime debars the centrally caused fall of the arterial pressure produced by armine, an inhibitor of cholinesterases readily gaining access into the brain. Diethyxime is(More)
As is known, 1,1-dimethyl-3-oxobutylphosphonic acid dimethyl ester (dimephosphon) exhibits antiinflammatory properties, although the mechanism of its action differs from that known in classical nonsteroidal drugs [1]. Recently we have demonstrated that some alkyldiphenylphosphin oxides possess antiinflananatory and/or analgesic properties [2]. The most(More)
We studied pro-cognitive effect of two heterocyclic low-molecular-weight compounds that serve as non-peptide analogues of soluble fragment of amyloid peptide precursor (sAPP). Intracerebroventricular and systemic administration of peptide mimetics P2 and P5 improved weak memory on the model of passive avoidance in chicks and in the object location task in(More)
Anti-inflammatory drugs (steroidal and nonsteroidal) are used to treat various inflammatory conditions. The use of steroids in clinical practice is subject to a number of restrictions due to side effects and complications [i, 2]. As a result, nonsteroidal antiinflammatory drugs (NSAIDs) have become more widely used, causing fewer side effects. NSAIDs(More)