B. J. Smith

Learn More
Dietary supplementation of dried plum (DP) prevents bone loss and restores bone mass in osteopenic animal models. This study was designed to determine the effects of DP supplementation on bone metabolic activity over time using adult (6-month-old) male C57BL/6 mice (n = 40) receiving control (CON = AIN93 M) or CON+DP 25 % (w/w) diets for 4 or 12 weeks.(More)
Scientists and engineers using supercomputer clusters should be able to focus on their scientific and technical work instead of worrying about operating their user environment. However, creating a convenient and effective user environment on modern supercomputers becomes more and more challenging due to the complexity of these large-scale systems. In this(More)
Measurement of in vitro and in vivo resistance to daunorubicin in AML patients suggests that there is no simple correlation between the two. In a patient who became clinically resistant and whose cells showed a parallel increased resistance in vitro we found the acquisition of multiple drug resistance. The increased in vitro resistance to daunorubicin could(More)
Daunorubicin and adriamycin are anthra-cycline drugs used in the chemotherapy of acute myelogenous leukaemia and other cancers (Crowther et al., 1973; Staquet et al., 1975). Their use is limited by their tendency to induce cardiac failure (Middleman, Luce and Frei, 1971; Malpas and Bodley Scott 1969), but there have been a number of reports (Lefrak et al.,(More)
  • 1