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tissues form a rational basis for the development of new cancer chemotherapeutic agents. These differences have been primarily uncovered and studied in rodent tumors and it seems essential to validate or invalidate the extra polation from rodent to human tumors by similar studies in human tumors (16). Ever since Warburg (18) reported the observation of a(More)
A combination of cyclophosphamide, adriamycin, methotrexate, and bleomycin (CAMB) was explored in patients with advanced, nonresectable epidermoid carcinoma from primary sites in the head and neck, recurrent or persistent after radiation or surgery. Objective regression (greater than 50%) of measurable tumor was present in 35% of the patients. The median(More)