B. J. Johnsen

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Caenorhabditis elegans strains carrying stress-reporter green fluorescent protein transgenes were used to explore patterns of response to metals. Multiple stress pathways were induced at high doses by most metals tested, including members of the heat shock, oxidative stress, metallothionein (mtl) and xenobiotic response gene families. A mathematical model(More)
Increasing evidence indicates that numerous genetic pathways responding to environmental stress in animals are regulated co-ordinately as well as independently. These stress-response systems should therefore be viewed in holistic terms as a network. As such, their behaviour is susceptible to mathematical modelling using a systems biology approach. This(More)
The erythemally weighted (UV) irradiance below the severely depleted Arctic vortices in spring 1996 and 1997 were substantially elevated. On average the UV increased 36 and 33% relative to the 1979–1981 mean assuming clear skies from day 80–100 in 1996 and 1997, respectively. On clear sky days large regions of the Arctic expe-5 rienced maximum UV increases(More)
The erythemally weighted (UV) irradiance below the severely depleted Arctic vortices in spring 1996 and 1997 were substantially elevated. On average the UV increased 36 and 33% relative to the 1979–1981 mean assuming clear skies from day 80–100 in 1996 and 1997, respectively. On clear sky days large regions of the Arctic experienced maximum UV increases(More)
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