B. J. Glasser

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Blending of powders is a crucial step in the production of pharmaceutical solid dosage forms. The active pharmaceutical ingredient (API) is often a powder that is blended with other powders (excipients) in order to produce tablets. The blending efficiency is influenced by several external factors, such as the desired degree of homogeneity and the required(More)
Pellets intended for oral dosing are frequently produced via extrusion/spheronization followed by drying. Typically, the last active process step, i.e., drying, is assumed to have little effect on the final dosage form properties (e.g., dissolution characteristics). Thus, there exist only a few studies of this subject. In the present study, calcium(More)
ecause the majority of active ingredients and excipients in drug products are powders, advances in pharmaceutical technology will be driven by improving the in-dustry's understanding of granular-material processing. In many cases, small amounts of active-drug crystals must be blended with large amounts of excipients with rather different physical(More)
T he last few lectures of an undergraduate class in fluid mechanics offer instructors an opportunity to teach students some advanced topics that go beyond the traditional course material. Fluid-particle flows, where both the fluid and particle are in motion, are prevalent in many industries including the chemical, materials, and energy industries. In the(More)
A cellular automata model is used to simulate a variety of granular chute flows. The model is tested against several case studies: flow down a chute, flow past an obstacle, chute flow in which complex, counter-rotating vortices result in streamwise surface stripes and flow near a boundary. The model successfully reproduces experimental observations in all(More)
We report on a newly discovered bifurcation that occurs in dry grains flowing down a chute with a wavy bottom. We find that the bifurcation outwardly resembles the long-know fluid analog of inviscid channel flow over a wavy bottom reported in 1886 by Lord Kelvin, however in detail the two situations differ significantly. We compare three distinct states(More)
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