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which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Discovery of estrogen receptor a target genes and response elements in breast tumor cells <p>Estrogens and their receptors are important in human development, physiology and disease. In this study, we utilized an integrated genome-wide(More)
The AP-2 clathrin adaptor differs fundamentally from the related AP-1, AP-3, and AP-4 sorting complexes because membrane deposition does not depend directly on an Arf family GTPase. Instead phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P(2)) appears to act as the principal compartmental cue for AP-2 placement at the plasma membrane as well as for the(More)
Clathrin-mediated endocytosis is an evolutionarily ancient membrane transport system regulating cellular receptivity and responsiveness. Plasmalemma clathrin-coated structures range from unitary domed assemblies to expansive planar constructions with internal or flanking invaginated buds. Precisely how these morphologically-distinct coats are formed, and(More)
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