B. Hetnarski

  • Citations Per Year
Learn More
Choline acetyltransferase (CAT) and acetylcholinesterase (AChE) activities were measured in spinal cord homogenates from rabbits with aluminum-induced neurofibrillary degeneration and a group of saline-treated, age-matched controls. All aluminum-treated animals showed neurofibrillary changes in the spinal cord, but CAT and AChE activities were not(More)
Regional distribution of choline acetyltransferase (CAT) and acetylcholinesterase (AChE) in seventeen regions of the rabbit CNS has been determined by means of the cation exchange radiometric method. A significant correlation has been found between the activities of AChE and CAT which allows computation of their potencies. A comparison between activities of(More)
  • B Hetnarski
  • Research communications in chemical pathology and…
  • 1979
Some properties of the charge-transfer constant (CT) have been described. The constant in association with the Hansch coefficient (pi, hydrophobic coefficient) for 32 aromatics was applied for the correlation with reciprocals of their acetylcholinesterase affinities (KD). The investigated aromatics constituted p- and m-substituted phenyl methylcarbamates,(More)
Eight novel methylcarbamates, derivates of ferrocenylketoximes and aldoximes, and ferrocenyl-p-hydroxyphenylaldimine were prepared. They are the first carbamates in the field of ferrocene derivatives. Their anticholinesterase activity was tested and found to fall in the range of 10(-4) through 10(-6) M (I50). The correlation between the activity of the(More)
A new, versatile constant accounting for the pi-complex formation ability of aromatic systems is proposed. The constant is derived from charge-transfer complex data of aromatic species (charge-transfer constant, CT). The applicability of CT in structure-reactivity relations is demonstrated. It is shown that the affinity of various inhibitors (32) and(More)
  • 1