B. Henrissat

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Ten years after the idea of hydrophobic cluster analysis (HCA) was conceived and first pub lished, theoretical and practical experience has shown this unconventional method of protein sequence anal ysis to be particularly efficient and sensitive, especially with families of sequences sharing low levels of se quence identity. This extreme sensitivity has(More)
Chitinases frequently display a modular structure featuring a catalytic domain attached to one or several ancillary noncatalytic domains whose function is often chitin binding. Gene cloning and DNA sequencing have allowed the determination of a massive number of amino acid sequences of chitinases during the last 10 years. This chapter presents a unifying(More)
Hydrophobic cluster analysis (HCA) is an efficient method for analysing and comparing the amino acid sequences of proteins. It relies on two-dimensional representations of the sequences presently generated by simple plot programs working on microcomputers. Two interactive programs, MANSEK and SUNHCA, are described here that operate from Vax and Sun(More)
A BASIC program, HCABAND, is described which is used to convert the linear amino acid sequence of proteins into a word processor-readable file to generate the 2D-helical representation required for hydrophobic cluster analysis. The user can specify the width of the plot and can use the word processor macro-commands to facilitate visual inspection of the(More)
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