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At present, likelihood ratios for two-level models are determined with the use of a normal kernel estimation procedure when the between-group distribution is thought to be non-normal. An extension is described for a two-level model in which the between-group distribution is very positively skewed and an exponential distribution may be thought to represent a(More)
We describe a concentric-flow electrokinetic injector for efficiently delivering microcrystals for serial femtosecond X-ray crystallography analysis that enables studies of challenging biological systems in their unadulterated mother liquor. We used the injector to analyze microcrystals of Geobacillus stearothermophilus thermolysin (2.2-Å structure),(More)
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