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Improved diagnostic tests for Chagas disease are urgently needed. A new lateral flow rapid test for Chagas disease is under development at PATH, in collaboration with Laboratorio Lemos of Argentina, which utilizes a recombinant antigen for detection of antibodies to Trypanosoma cruzi. To evaluate the performance of this test, 375 earlier characterized serum(More)
within the PIPAAm-modified capillary at 30 °C and burst release during PIPAAm collapse. This burst is analogous to drug release from collapsing PIPAAm gel disks undergoing analogous thermal treatment. [17] Similarly, just after each temperature return to 30 °C, small fluorescent spikes are observed. In contrast, oscillatory fluorescent changes have been(More)
Current frameworks for evaluating diagnostic tests are constrained by a focus on diagnostic accuracy, and assume that all aspects of the testing process and test attributes are discrete and equally important. Determining the balance between the benefits and harms associated with new or existing tests has been overlooked. Yet, this is critically important(More)
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