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Hepatitis C virus (HCV) forms complex quasispecies populations which consist of a large number of closely related genetic variants. This genetic heterogeneity may cause antigenic variation or drug resistance. We used heteroduplex analysis by temperature gradient gel electrophoresis (TGGE) to characterize genetic variants of HCV. The high resolution of TGGE(More)
Genetic variants of HCV may have different degrees of resistance to IFN and may therefore influence the outcome of IFN therapy. However, selection of HCV variants by IFN has not been investigated in detail. In this paper, heteroduplex analysis was used to monitor major changes of HCV populations in 4 chronically infected patients under IFN therapy. We found(More)
Cell membrane receptors play a central role in controlling cellular functions, making them the target of drugs for a wide variety of diseases. This report describes how a recently developed method, fluorescence intensity distribution analysis (FIDA), can be used to develop homogeneous, nonradioactive high throughput screening assays for membrane receptors.(More)
[1] Nukt idkar te , 3 -Auf l . (1968). B u n d e s m i n . f. wiss. For schung . M~nchen : Verlag Gersbach & S o h n . [2] K u h l m a n n , A. : E in f f ih rung i. d. P rob leme der Kern reak to r s i che r heir. Dflsseldorf: VDI-Ver lag t967. [3] Glantz, H., Heinrich, B., Kiefer, H . : K e r n t e c h n i k 11, 255 (t969). [4~ Kiefer, H . : K a t a s t r(More)
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