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Objective: To compare the effects of dopexamine and dopamine on the mucosal permeability of the gastrointestinal tract (GIT). Design: Prospective, randomised clinical trial. Setting: Intensive care unit of a postgraduate teaching hospital, London, England. Patients: Thirty patients undergoing elective surgery involving cardiopulmonary bypass, performed by a(More)
INTRODUCTION This report describes the case mix, outcome and activity (duration of intensive care unit [ICU] and hospital stay, inter-hospital transfer, and readmissions to the ICU) for admissions to ICUs for acute severe asthma, and investigates the effect of case mix factors on outcome. METHODS We conducted a secondary analysis of data from a(More)
BACKGROUND A study was undertaken to investigate possible reductions in mortality and/or changes in outcome predictive factors in patients with the acute respiratory distress syndrome (ARDS) managed in a single centre. METHODS The study was a prospective observational cohort study of two patient populations with ARDS. Group 1 comprised 41 patients(More)
BACKGROUND Lung delivery of plasmid DNA encoding the CFTR gene complexed with a cationic liposome is a potential treatment option for patients with cystic fibrosis. We aimed to assess the efficacy of non-viral CFTR gene therapy in patients with cystic fibrosis. METHODS We did this randomised, double-blind, placebo-controlled, phase 2b trial in two cystic(More)
The average daily dietary intake of 88 idiopathic renal stone cases and 88 age and sex matched controls was assessed by history using a standardised questionnaire. Statistical analysis was undertaken on the whole group and on male and female subgroups, to establish if there were any significant differences between cases and controls. There were(More)
OBJECTIVE To assess the possibility that acute respiratory distress syndrome (ARDS) of pulmonary and nonpulmonary origins represent two distinct syndromes. DESIGN Analysis of data collected prospectively from an inception cohort of 117 patients with ARDS. SETTING Adult intensive care unit (ICU), university/postgraduate hospital. MEASUREMENTS AND MAIN(More)
To study the impact of continuous veno-venous haemofiltration on survival in patients with acute renal failure (ARF) following cardio-pulmonary bypass (CPB) surgery. A retrospective study of all patients requiring haemofiltration after CPB over a 2 year period. A 20 bedded, adult cardothoracic intensive care unit in a postgraduate teaching hospital. 35(More)
STUDY OBJECTIVES To identify serial changes in the appearances of the lungs on computed tomography (CT) in patients with established adult respiratory distress syndrome (ARDS). Second, to evaluate any relationship between the extent of morphologic abnormalities on CT anatomic and physiologic derangement using a numeric score of the severity of lung injury.(More)