Cerebrospinal fluid (CSF) from 8 patients with symptomatic infantile spasms was collected before specific treatment for infantile spasms. The concentration of CSF kynurenic acid (KYA) and 3-hydroxykynurenine (3-OHKY) in infantile spasms was analyzed by high-performance liquid chromatography and compared with CSF KYA from 10 age-matched controls. The levels… (More)
Kynurenic acid (KYA), the only known endogenous antagonist of the excitatory amino acids, is a metabolite of kynurenine. In the present study the levels of KYA were measured in the cerebrospinal fluid (CSF) of epileptic children and age-matched controls to investigate the relationship between various forms of epilepsy and KYA levels. CSF samples from four… (More)
Changes in cerebrospinal fluid (CSF) neurotransmitter metabolite concentrations in 32 neurologically normal children aged 0 month to 7 years were analyzed to assess maturation of the central nervous system and compared to CSF from adults. Significant inverse correlations with aging were observed for tryptophan, 5-hydroxyindoleacetic acid, kynurenine,… (More)
Cerebrospinal fluid (CSF) from 6 cases of asymptomatic infantile spasms (IS) (mean age, 6.1 months) was collected before and after treatment with adrenocorticotropic hormone (ACTH). The concentration of CSF tryptophan (TRP) metabolites was analyzed using HPLC and compared to the metabolite concentration in CSF from 10 age-matched controls (mean age, 6.7… (More)
(1) This is the first study to demonstrate that CSF 5HTP, HVA and DOPAC of asphyxiated newborns are higher than those of healthy newborn infants. (2) This study shows Neurochem, a newly developed neurochemical analyzer, is useful equipment in neonatal neurological research.
The present study examined effects of variations in modeled pain cues on level of vicarious arousal, using heart rate and blood-volume amplitude as psychophysiological measures. Students were assigned randomly to one of four groups in which they either (a) underwent directly the cold-pressor test, (b) observed a model exposed to the cold-pressor test and… (More)