B. E. Maimon

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The prefrontal cortex (PFC) has been implicated in the maintenance of task-relevant information during goal-directed behavior. Using a combination of lesions, local inactivation, and optogenetics, we investigated the functional role of the medial prefrontal cortex (mPFC) in mice with a novel operant delayed alternation task. Task difficulty was manipulated(More)
OBJECTIVE A fundamental limitation in both the scientific utility and clinical translation of peripheral nerve optogenetic technologies is the optical inaccessibility of the target nerve due to the significant scattering and absorption of light in biological tissues. To date, illuminating deep nerve targets has required implantable optical sources,(More)
Prosthetic limb control is fundamentally constrained by the current amputation procedure. Since the U.S. Civil War, the external prosthesis has benefited from a pronounced level of innovation, but amputation technique has not significantly changed. During a standard amputation, nerves are transected without the reintroduction of proper neural targets,(More)
34 The prefrontal cortex (PFC) has been implicated in the maintenance of task-relevant information 35 during goal-directed behavior. Using a combination of lesions, local inactivation, and 36 optogenetics, we investigated the functional role of the medial prefrontal cortex (mPFC) in mice 37 using a novel operant delayed alternation task. Task difficulty was(More)
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