B. E. Kristensson

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In a double-blind study with parallel groups a new controlled-release (CR) formulation of metoprolol1, 100 mg once daily, was compared with conventional metoprolol tablets, 100 mg once daily, in 27 patients with primary hypertension. Exercise tests on a bicycle ergometer were undertaken 24 h after intake of the last dose of the drug following a four-week(More)
To compare the added haemodynamic importance of atrioventricular synchrony to rate increase, we studied 10 patients, healthy except for atrioventricular block, treated with atrioventricular synchronous pacemakers. Haemodynamic data were obtained by brachial and pulmonary arterial catheterisation. Recordings were made at rest and during upright bicycle(More)
AIMS The aim of this study was to examine the effect on symptoms in patients with induced cardioinhibitory carotid sinus syndrome (ICSS) when treated or not treated with a pacemaker. METHODS AND RESULTS Sixty patients with a history of syncope or pre-syncope and ICSS were randomized to receive a permanent pacemaker (P group, n = 30) or no pacing (NP(More)
Patients with sinus node disease (SND) who are unable to achieve an adequate increase in heart rate during exercise are candidates for atrial rate-responsive pacing (AAI-R). We have implanted 40 AAI-R systems in SND patients with an average follow-up of 12.5 +/- 8 (range 3-30) months. All the patients received an activity-sensing pulse generator(More)
The clinical applicability of rate-responsive pacing (RRP) by means of activity sensing has been tested in 15 patients. The patients (ages 24-85) had sinus node dysfunction (2), atrial fibrillation (7), or sinus rhythm (6) combined with complete atrioventricular block. Exercise capacity was investigated on a bicycle ergometer and on a treadmill in a(More)
Previous comparisons of physiological and single-rate ventricular pacing are mostly based on open studies. The present investigation was designed to control possible biases of such a study design with the aim to investigate effects of the two pacing modes on maximal and submaximal exercise tolerance and the subjective feeling of well-being of the patients.(More)
In order to determine whether different atrioventricular intervals influence the maximal exercise capacity, 15 patients with second degree or complete atrioventricular block and no signs of left ventricular failure were studied. They all had atrioventricular synchronous pacemakers. Maximal exercise tests (sitting bicycle ergometry) were performed at four(More)
Atrial synchronous pacing has been considered contraindicated in patients with a high degree of atrioventricular block and concomitant ischaemic heart disease. The rationale for this view was a fear of provoking angina pectoris by a rate-dependent increase in myocardial oxygen consumption. As possible problems with atrial synchronous pacing in patients with(More)
The purpose of this investigation was to study rate variability during normal everyday activities among physiologically paced patients. A comparison of the spontaneous occurrence of arrhythmias with ventricular inhibited pacing was also made. VDD pacemakers in 44 patients were randomly programmed to three-week long periods of VVI (70 bpm) or VDD (back-up(More)
Fifty-four VDD-paced patients were followed for more than 12 months; they were studied retrospectively in order to assess possible clinical problems and their management. The patients were between 19 and 84 years of age (mean, 66 +/- 11). Twenty-four of the 54 received a VDD pacemaker as a primary implant and 30 had had VVI pacemakers which were changed to(More)
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