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. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . xv Chapter 1 Decomposition-based Design Optimization . . . . . . . . . . . . . . 1 1.1 Engineering System Design . . . . . . . . . . . . . . . . . . . . . . . . . . 2 1.2 Design Optimization . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 4 1.3 Decomposition-based(More)
This paper provides an introduction to a new method for distributed optimization based on collaborative optimization, a decomposition-based method for the optimization of complex multidisciplinary designs. The key idea in this approach is to include models of the global objective and all of the subspace constraints in each subspace optimization problem(More)
In vivo evidence for brain mitochondrial dysfunction in animal models of Huntington disease (HD) is scarce. We applied the novel 17O magnetic resonance spectroscopy (MRS) technique on R6/2 mice to directly determine rates of oxygen consumption (CMRO2) and assess mitochondrial function in vivo Basal respiration and maximal CMRO2 in the presence of the(More)
This paper explores the use of decomposition-based methods for aircraft family design. The traditional approach in multidisciplinary design optimization is to decompose a problem along disciplinary lines. For aircraft family design problems, a more natural approach is decomposition by individual aircraft. This decomposition facilitates the concurrent(More)
Astute choices made early in the design process provide the best opportunity for reducing the life cycle cost of a new product. Optimal decisions require reasonably detailed disciplinary analyses, which pose coordination challenges. These types of complex multidisciplinary problems are best addressed through the use of decomposition-based methods, several(More)
T h i s p a p e r p r e s e n t s a r u l e b a s e d a p p r o a c h t o t h e d e v e l o p m e n t o f an e x p e r t s y s t e m t o manage a patient ventilator system without operator intervention. It is designed to stabilize chemical warfare casualties during their transit from battlefields to well-equlpped medical centers. The system performs its(More)
We discuss efficient algorithms for the accurate forward and reverse evaluation of the discrete Fourier-Bessel transform (dFBT) as numerical tools to assist in the 2D polar convolution of two radially symmetric functions, relevant, e.g., to applications in computational biophotonics. In our survey of the numerical procedure we account for the circumstance(More)
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