B D Muller

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Using a technique by which binding sites for two antibodies can be visualized in single tissue sections, we have studied the distribution of neurones containing DOPA decarboxylase-like and dopamine beta-hydroxylase-like immunoreactivity in ganglia of dog sympathetic chain. Three types of neurones could be distinguished: those that contained both enzymes,(More)
The subcellular distribution of 3,4-dihydroxyphenylethylamine (DA, dopamine) and noradrenaline was examined in preparations of dog spleen and renal cortex following ultracentrifugation on a discontinuous sucrose gradient. In both tissues, only half the total tissue DA was localized to the soluble phase, and 30-50% was found in association with noradrenaline(More)
Previous pharmacological and biochemical findings have suggested the presence of dopaminergic vasomotor neurones in the sympathetic outflows to the kidney and the digits of the dog. In the present study, we have used histochemical techniques to compare the distributions of catecholamines and dopamine-beta-hydroxylase-like immunoreactivity in ganglion cell(More)
AIM In endothelium-denuded arteries, the nitric oxide (NO) donor S-nitrosoglutathione (GSNO) induced a persistent hypo-reactivity to vasoconstrictors, and low-molecular weight thiols such as N-acetyl cysteine (NAC) produced a relaxant effect. These effects were attributed to the formation of vascular NO stores. In arteries with a functional endothelium,(More)
The study was undertaken to examine LH, prolactin (Prl) and estradiol involvement in the control of corpus luteum function during 4-day cycle in the female rat. A potent LHRH antagonist (Antag) and bromocriptine (BRC) were used to induce LH and Prl deprivation in 4-day cyclic rats. Both drugs were administered after the occurrence of LH and Prl release on(More)
We have compared the pattern of neural catecholamine fluorescence with that of immunoreactivity for the catecholamine-synthesizing enzymes tyrosine hydroxylase (TH) and DOPA decarboxylase (DDC) in dog atrium, which is innervated by noradrenergic nerves, and in dog kidney, which is thought to be supplied by dopaminergic nerves as well. In both tissues the(More)
Some of the paravertebral sympathetic ganglia of the dog contain relatively large amounts of dopamine, which we have suggested previously is localized in dopaminergic neurones. However, the possibility exists that intraganglionic chromaffin-like cells may also be a source of dopamine. In order to resolve this question, we have examined the distribution of(More)
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