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The Micro-Rato Contest of the University of Aveiro is a competition among small autonomous mobile robots that is organized by the Electronics, Telecommunications and Informatics Department of that institution. The contest aims at promoting, in a festival-like environment, the practical and integrated use of several topics typically taught in electronics and(More)
Mobile Robot competitions are an important way for dissemination of science and engineering to the general public but are also excellent way of testing and comparing different research strategies. In this paper we discuss how today’s research challenges of Intelligent and Autonomous Mobile Robots are being handled by the Autonomous Driving competition that(More)
Current wireless communication systems rely on the assumptions of the Nyquist theorem. Faster-Than-Nyquist (FTN) assumes that a bandwidth below the Nyquist bandwidth can be used with minimum loss, however the existing receivers are too complex. Single Carrier with Frequency-Domain Equalization (SC-FDE) has been proposed to handle multipath dispersive(More)
To deliver the required cell numbers and doses to therapy, scaling-up production and purification processes (at least to the liter-scale) while maintaining cells' characteristics is compulsory. Therefore, the aim of this work was to prove scalability of an integrated streamlined bioprocess compatible with current good manufacturing practices (cGMP)(More)
Carboxylesterase 2 (CES2), the main carboxylesterase expressed in human intestine, is an increasingly important enzyme in anti-cancer combined therapies for the treatment of different pathologies like colon adenocarcinoma and malignant glioma. The production of human recombinant CES2, in human embryonic kidney cells (HEK-293T cells) using serum-free media,(More)
The use of human mesenchymal stem cells (hMSC) in clinical applications has been increasing over the last decade. However, to be applied in a clinical setting hMSC need to comply with specific requirements in terms of identity, potency and purity. This study reports the improvement of established tangential flow filtration (TFF)-based washing strategies,(More)
The integration of up- and downstream unit operations can result in the elimination of hold steps, thus decreasing the footprint, and ultimately can create robust closed system operations. This type of design is desirable for the bioprocess of human mesenchymal stem cells (hMSC), where high numbers of pure cells, at low volumes, need to be delivered for(More)
Background During the past decade, human stem cells have been the focus of an increased interest due to their potential in clinical applications, as a therapeutic alternative for several diseases. Within this context, human mesenchymal stem cells (hMSCs) have gained special attention due to their immune-modulatory characteristics, as well as in secreting(More)
Gradients of physical and chemical cues are characteristic of specific tissue microenvironments and contribute toward morphogenesis and tissue regeneration upon injury. Recent advances on microfluidics and hydrogel manipulation raised the possibility of generating biomimetic biomaterials enriched with bioactive factors and encapsulating cells following(More)
This paper describes the work undertaken, in a two-weeks time, to put a robotic football player doing autonomous driving in a robotics contest. The robot was designed to play football in the RoboCup middle size league, and was used without modifications. During competition, it has to complete two laps of a circuit, autonomously, as fast as possible, and(More)