B. Ciminaghi

Learn More
S. Mazzola1, M. Forni2, M. Albertini1*, M.L. Bacci2, B. Ciminaghi1, M. Lavitrano3, E. Seren2 and M.G. Clement1 1Department of Animal Pathology, Hygiene and Public Veterinary Health, Section of Biochemistry and Physiology, University of Milan, Italy; 2Department of Veterinary Morphophysiology and Animal Production, University of Bologna, Italy; 3Department(More)
We evaluated the role of endothelin-1 (ET-1) and the involvement of nitric oxide in cardiovascular and respiratory dysfunction, during endotoxic shock, in 18 anaesthetised, mechanically ventilated pigs, divided into three groups. Group 1 was i.v. infused with LPS (20 microg/Kg/h for 240 min). Group 2 was pre-treated with bosentan, a dual inhibitor of ET-1(More)
B. Ciminaghi1 , M. Albertini1* , C.L. Lafortuna2, S. Mazzola1 , M.G. Clement1 1Dipartimento di Patologia Animale, Igiene e Sanità Pubblica Veterinaria, Sezione di Biochimica e Fisiologia, Università degli Studi di Milano; 2Istituto di Bioimmagini e Fisiologia Molecolare del Consiglio Nazionale delle Ricerche, Milano, Italy *Correspondence: Dipartimento di(More)
To evaluate the role of endothelin (ET) in respiratory homeostasis we studied the effects of the ET(A) and ET(B) receptor blocking agent bosentan on respiratory mechanics and control in seven anaesthetised spontaneously breathing pigs, for 180 min after single bolus administration (20 mg/kg i.v.). The results show that the block of ET receptors induced a(More)
We evaluated the endothelin-1 (ET-1) and thrombin involvement in cardiovascular and respiratory dysfunction during endotoxic shock in 18 anaesthetized, mechanically ventilated pigs, divided into three groups. Group 1 was pre-treated only with lipopolysaccharide (LPS), group 2 was treated with lepirudin, a thrombin inhibitor, group 3 was pre-treated with(More)
B. Ciminaghi, M. Albertini*, M. Costanzi, F. Patrese and M.G. Clement Department of Animal Pathology, Hygiene and Public Veterinary Health – Section of Biochemistry and Physiology, University of Milan, V ia Celoria, 10, 20133 Milan, Italy *Correspondence: Dipartimento di Patologia Animale, Igiene e Sanità Pubblica Veterinaria, Sezione di Biochimica e(More)
  • 1