The first documented case of a symptomatic intrasellar hemangioblastoma is described, occurring in an 11-year-old girl with stigmata of von Hippel-Lindau disease who presented with headaches, progressive bitemporal hemianopsia, and adenohypophysial dysfunction. A subtotal resection of the lesion was achieved with two separate surgical procedures: a… (More)
In selected patients with recurrent malignant glioma, interstitial brachytherapy has been advocated as an effective method for tumor control and prolonged survival. We are presenting our results with brachytherapy in patients with recurrent glioma, and comparing this technique with cytoreductive surgery. Twenty patients (9 male, 11 female) underwent… (More)
Stereotactic radiosurgery has become a more widely employed modality of treatment for acoustic neuromas, but controversy still arises regarding the safety and efficacy of the technique. In general, radiation doses have been reduced over time. Since beginning treatments of acoustic neuromas with the Gamma Knife at the University of Miami/Jackson Memorial… (More)
PURPOSE To investigate the cost-effectiveness of high-dose MR contrast studies in the management of brain metastases. METHODS During the phase III clinical trial of high-dose contrast studies (0.3 mmol/kg), 11 of 27 patients were judged by the reviewers to have potential treatment changes based on the additional information provided by the high-dose… (More)
Vorinostat, a histone deacetylase (HDAC) inhibitor, is a promising agent for cancer therapy. Combining vorinostat with cisplatin may relax the chromatin structure and facilitate the accessibility of cisplatin, thus enhancing its cytotoxicity. Studies have not yet investigated the effects of the combination of vorinostat and cisplatin on small cell lung… (More)
Twelve consecutive patients with recurrent malignant glioma were treated with brachytherapy. Thereafter, a prospective randomized study involving 35 patients was undertaken. Although additional study is necessary, preliminary recommendation calls for treatment at diagnosis rather than at recurrence.
Stereotactic interstitial brain implants deliver locally high radiation doses to treat malignant gliomas. Dose to the surrounding normal brain from an 125I implant has been compared with the dose from an external irradiation technique. Results show that an implant offers a higher dose gradient around the tumor and hence a lower dose to the normal brain.… (More)